1. Gene
  2. CDKN2C - cyclin dependent kinase inhibitor 2C Gene

CDKN2C - cyclin dependent kinase inhibitor 2C Gene

中文名称:细胞周期蛋白依赖性激酶抑制因子 2C

种属: Homo sapiens

同用名: p18; INK4C; p18-INK4C

基因 ID: 1031 | 基因类型: protein coding

关于 CDKN2C

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:50,968,706-50,974,634 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 72 phenotypes. Broad expression in fat (RPKM 34.6), ovary (RPKM 9.5) and 22 other tissues.

功能概要

该基因编码的蛋白质是细胞周期蛋白依赖性激酶抑制剂 INK4 家族的成员。这种蛋白质已被证明与 CDK4CDK6 相互作用,并阻止 CDK 激酶的激活,因此起到控制细胞周期 G1 进程的细胞生长调节剂的作用。该基因的异位表达被证明以一种似乎与野生型 RB1 功能的存在相关的方式抑制人类细胞的生长。对敲除小鼠的研究表明该基因在调节精子发生以及抑制肿瘤发生方面的作用。已经报道了该基因的两种选择性剪接的转录物变体,它们编码相同的蛋白质。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

CDKN2C 基因产物(2)

mRNA Protein Name
NM_001262.3 NP_001253.1 cyclin-dependent kinase 4 inhibitor C
NM_078626.3 NP_523240.1 cyclin-dependent kinase 4 inhibitor C

CDKN2C 蛋白结构

Ank_4

Ank_4: Ankyrin repeats (many copies) (10 - 43)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (46 - 127)

  • 0
  • 100
  • 168 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 4 inhibitor C

CDK6 inhibitor p18

CDKN2C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDKN2C P42773 PBX4 Homo sapiens Q9BYU1 32296183
种属内
CDKN2C P42773 PBX4 Homo sapiens Q9BYU1 32296183
种属内
CDKN2C P42773 PBX4 Homo sapiens Q9BYU1 32296183
种属内
CDKN2C P42773 REL Homo sapiens Q04864-2 25910212
种属内
CDKN2C P42773 REL Homo sapiens Q04864-2 25910212
种属内
CDKN2C P42773 REL Homo sapiens Q04864-2 25910212
种属内
CDKN2C P42773 NAGK Homo sapiens Q9UJ70-2 25910212
种属内
CDKN2C P42773 NAGK Homo sapiens Q9UJ70-2 25910212
种属内
CDKN2C P42773 NAGK Homo sapiens Q9UJ70-2 25910212
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081-3 25910212
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081-3 25910212
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081-3 31515488
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081-3 25910212
种属内
CDKN2C P42773 POU6F2 Homo sapiens P78424 32296183
种属内
CDKN2C P42773 POU6F2 Homo sapiens P78424 32296183
种属内
CDKN2C P42773 TCF4 Homo sapiens P15884-3 25910212
种属内
CDKN2C P42773 TCF4 Homo sapiens P15884-3 25910212
种属内
CDKN2C P42773 TCF4 Homo sapiens P15884-3 25910212
种属内
CDKN2C P42773 LAMP2 Homo sapiens P13473-2 32814053
种属内
CDKN2C P42773 LAMP2 Homo sapiens P13473-2 32814053
种属内
CDKN2C P42773 LAMP2 Homo sapiens P13473-2 32814053
种属内
CDKN2C P42773 AHCYL1 Homo sapiens O43865 25416956
种属内
CDKN2C P42773 AHCYL1 Homo sapiens O43865 25910212
种属内
CDKN2C P42773 AHCYL1 Homo sapiens O43865 32296183
种属内
CDKN2C P42773 AHCYL1 Homo sapiens O43865 32296183
种属内
CDKN2C P42773 AHCYL1 Homo sapiens O43865 25910212
种属内
CDKN2C P42773 AHCYL1 Homo sapiens O43865 25910212
种属内
CDKN2C P42773 CDK4 Homo sapiens P11802 17353931
种属内
CDKN2C P42773 CDK4 Homo sapiens P11802 32296183
种属内
CDKN2C P42773 CDK4 Homo sapiens P11802 31515488
种属内
CDKN2C P42773 CDK4 Homo sapiens P11802 27107012
种属内
CDKN2C P42773 CDK4 Homo sapiens P11802 28514442
种属内
CDKN2C P42773 CDK4 Homo sapiens P11802 32296183
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 17353931
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 25910212
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 25910212
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 27107012
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 25910212
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 25416956
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534 25416956
种属内
CDKN2C P42773 CDK6 Homo sapiens Q00534
SLC
25910212
种属内
CDKN2C P42773 REL Homo sapiens Q04864 25416956
种属内
CDKN2C P42773 NAGK Homo sapiens Q9UJ70 25416956
种属内
CDKN2C P42773 HIP1 Homo sapiens O00291 32814053
种属内
CDKN2C P42773 HIP1 Homo sapiens O00291 32814053
种属内
CDKN2C P42773 HIP1 Homo sapiens O00291 32814053
种属内
CDKN2C P42773 PRPF40A Homo sapiens O75400-2 32814053
种属内
CDKN2C P42773 PRPF40A Homo sapiens O75400-2 32814053
种属内
CDKN2C P42773 PRPF40A Homo sapiens O75400-2 32814053
种属内
CDKN2C P42773 TCF4 Homo sapiens P15884 25416956
种属内
CDKN2C P42773 TCF4 Homo sapiens P15884 25416956
种属内
CDKN2C P42773 TCF4 Homo sapiens P15884 25416956
种属内
CDKN2C P42773 CASP6 Homo sapiens P55212 32814053
种属内
CDKN2C P42773 CASP6 Homo sapiens P55212 32814053
种属内
CDKN2C P42773 CASP6 Homo sapiens P55212 32814053
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081 31515488
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081 25416956
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081 25416956
种属内
CDKN2C P42773 TCF12 Homo sapiens Q99081 25416956
种属内
CDKN2C P42773 NIF3L1 Homo sapiens Q9GZT8 25910212
种属内
CDKN2C P42773 NIF3L1 Homo sapiens Q9GZT8 25910212
种属内
CDKN2C P42773 NIF3L1 Homo sapiens Q9GZT8 25910212
种属内
CDKN2C P42773 SORBS3 Homo sapiens O60504 32296183
种属内
CDKN2C P42773 SORBS3 Homo sapiens O60504 32296183
种属内
CDKN2C P42773 CRX Homo sapiens O43186 32296183
种属内
CDKN2C P42773 CRX Homo sapiens O43186 32296183
种属内
CDKN2C P42773 CTDSP1 Homo sapiens Q9GZU7 32296183
种属内
CDKN2C P42773 CTDSP1 Homo sapiens Q9GZU7 32296183
种属内
CDKN2C P42773 CTDSP1 Homo sapiens Q9GZU7 32296183
种属内
CDKN2C P42773 KRT31 Homo sapiens Q15323 32296183
种属内
CDKN2C P42773 KRT31 Homo sapiens Q15323 32296183
种属内
CDKN2C P42773 PLEKHG4 Homo sapiens Q58EX7 32296183
种属内
CDKN2C P42773 PLEKHG4 Homo sapiens Q58EX7 32296183
种属内
CDKN2C P42773 PLEKHG4 Homo sapiens Q58EX7 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CDKN2C 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70034 CDKN2C Protein, Human (His) P42773 (M1-Q168) ≥95%

CDKN2C 抗体

目录号 产品名 应用 反应物种
HY-P81003 CDKN2C Antibody WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia

Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia

Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Anaplastic Oligodendroglioma
Parathyroid Adenoma

Adenoma Of Parathyroid

Adenoma Of The Parathyroid Gland

Parathyroid Gland Adenoma

Multiple Endocrine Neoplasia

Men

Multiple Endocrine Adenomatosis

Multiple Endocrine Neoplasia Syndrome

Adenomatosis, Familial Endocrine

Endocrine Neoplasia, Multiple

Familial Endocrine Adenomatosis

Mea

Multiple Endocrine Neoplasms

Multiple Endocrine Neoplasia Type 1

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Acute Leukemia

Stem Cell Leukaemia

Stem Cell Leukemia

Acute Leukemias

Acute Undifferentiated Leukemia

Undifferentiated Leukemia

Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

Blast Cell Leukaemia

Blast Leukaemia

Blastic Leukaemia

Undifferentiated Leukaemia

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Multiple Endocrine Neoplasia, Type Iv

Multiple Endocrine Neoplasia Type 4

MEN4

Multiple Endocrine Neoplasia 4

Neoplasia, Endocrine, Multiple, Type Iv

Water-Clear Cell Adenoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia

Fbh

Fbhh

Fhh

Familial Benign Hypocalciuric Hypercalcemia

Hypocalciuric Hypercalcemia, Familial, Type 1

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CDKN2C VGNC VGNC:107506
Macaca mulatta CDKN2C VGNC VGNC:97747
Rattus norvegicus CDKN2C RGD RGD:2325
Mus musculus CDKN2C MGD MGI:105388
Bos taurus CDKN2C VGNC VGNC:27146
Canis familiaris CDKN2C VGNC VGNC:39072
Others CDKN2C NCBI