NAGK - N-acetylglucosamine kinase Gene

中文名称：N-乙酰葡糖胺激酶

种属: Homo sapiens

同用名: GNK; HSA242910

基因 ID: 55577 | 基因类型: protein coding

关于 NAGK

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:71,068,296-71,079,808 (from NCBI)

This gene has 29 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in spleen (RPKM 27.6), esophagus (RPKM 26.3) and 25 other tissues.

功能概要

该基因编码 N-乙酰己糖胺激酶家族的一个成员。所编码的蛋白质催化 N-乙酰-D-氨基葡萄糖转化为 N-乙酰-D-氨基葡萄糖 6-磷酸，是哺乳动物回收氨基糖的主要酶。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian Enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

NAGK 基因产物(4)

mRNA	Protein	Name
NM_001330425.3	NP_001317354.1	N-acetyl-D-glucosamine kinase isoform 2
NM_001330426.2	NP_001317355.1	N-acetyl-D-glucosamine kinase isoform 2
NM_001365466.2	NP_001352395.1	N-acetyl-D-glucosamine kinase isoform 2
NM_017567.6	NP_060037.4	N-acetyl-D-glucosamine kinase isoform 1

NAGK 蛋白结构

BcrAD_BadFG

0
100
200
300
344 a.a.

蛋白主名

其他名称

N-acetyl-D-glucosamine kinase

epididymis secretory sperm binding protein

NAGK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NAGK	Q9UJ70	ACTR10	Homo sapiens	Q9NZ32	Y2H Prey Pooling	25416956
种属内	NAGK	Q9UJ70	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
种属内	NAGK	Q9UJ70	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	25416956
种属内	NAGK	Q9UJ70	REL	Homo sapiens	Q04864	Validated Y2H	25416956
种属内	NAGK	Q9UJ70	REL	Homo sapiens	Q04864	Y2H Array	25416956
种属内	NAGK	Q9UJ70	DACH1	Homo sapiens	Q9UI36	Y2H	21516116
种属内	NAGK	Q9UJ70	CDKN2C	Homo sapiens	P42773	Y2H Array	31515488
种属内	NAGK	Q9UJ70	CDKN2C	Homo sapiens	P42773	Y2H Prey Pooling	25416956
种属内	NAGK	Q9UJ70	CDKN2C	Homo sapiens	P42773	Validated Y2H	25416956
种属内	NAGK	Q9UJ70	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
种属内	NAGK	Q9UJ70	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
种属内	NAGK	Q9UJ70	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
种属内	NAGK	Q9UJ70	LNX1	Homo sapiens	Q8TBB1	Pull Down	16189514
种属内	NAGK	Q9UJ70	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
种属内	NAGK	Q9UJ70	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
种属间	NAGK	Q9UJ70	Snrpn	Rattus norvegicus	P63164	Anti Tag CoIP	37511433
种属间	NAGK	Q9UJ70	Snrpn	Rattus norvegicus	P63164	Pull Down	37511433

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nonaka Myopathy

Gne Myopathy	Hibm
Distal Myopathy With Rimmed Vacuoles	Hereditary Inclusion Body Myopathy
Ibm2	Inclusion Body Myopathy, Quadriceps-Sparing
Qsm	Dmrv
Distal Myopathy, Nonaka Type	Inclusion Body Myopathy 2
Inclusion Body Myopathy, Autosomal Recessive	NM
Nonaka Distal Myopathy	Myopathy, Distal, With Or Without Rimmed Vacuoles
Inclusion Body Myopathy, Hereditary, Autosomal Recessive	Inclusion Body Myopathy Type 2
Quadriceps-Sparing Myopathy	Quadriceps Sparing Myopathy
Rimmed Vacuole Myopathy	Inclusion Body Myopathy 2, Autosomal Recessive, Formerly
Ibm2, Formerly	Hibm2
Hereditary Inclusion Body Myopathy Type 2	Inclusion Body Myopathy 2, Autosomal Recessive
Myopathy, Distal, With Rimmed Vacuoles	Inclusion Body Myopathy Autosomal Recessive
Myopathy, Inclusion Body, Type 2	Myopathy, Nonaka

Sialuria

Sialuria, French Type	French Type Sialuria
Sialuria French Type	Sialic Acid Storage Disease
Sialic Acid Storage Disease, Finnish Type	Infantile Sialic Acid Storage Disease

Chronic Monocytic Leukemia

Leukemia, Myeloid

Leukemia, Monocytic, Chronic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09010	NAGK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NAGK	RGD	RGD:1305057
Macaca mulatta	NAGK	VGNC	VGNC:74977
Bos taurus	NAGK	VGNC	VGNC:31868
Mus musculus	NAGK	MGD	MGI:1860418
Felis catus	NAGK	VGNC	VGNC:63713

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