2. Gene
  3. DACH1 - dachshund family transcription factor 1 Gene

DACH1 - dachshund family transcription factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腊肠犬家族转录因子 1

种属: Homo sapiens

同用名: DACH

基因 ID: 1602 | 基因类型: protein coding

关于 DACH1

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:71,437,966-71,867,204 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 3.2), gall bladder (RPKM 2.4) and 21 other tissues.

功能概要

该基因编码一种染色质相关蛋白，该蛋白与其他 DNA 结合转录因子结合，在发育过程中调节基因表达和细胞命运决定。该蛋白质包含一个从果蝇到人类高度保守的 Ski 结构域。该基因的表达在某些形式的转移性癌症中丢失，并且与不良预后相关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 9 月]

This gene encodes a chromatin-associated protein that associates with Other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic Cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

DACH1 基因产物(4)

mRNA Protein Name
NM_001366712.1 NP_001353641.1 dachshund homolog 1 isoform d
NM_004392.7 NP_004383.4 dachshund homolog 1 isoform c
NM_080759.6 NP_542937.3 dachshund homolog 1 isoform a
NM_080760.6 NP_542938.3 dachshund homolog 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20956529 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20956529 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20956529 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14525983 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA biosynthetic process IDA
IDA: 通过直接分析推断
16980615 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
21750150 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
20956529 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20956529 GOA
involved in negative regulation of transcription by competitive promoter binding IMP
IMP: 通过突变表型推断
20956529 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DACH1 蛋白结构

Ski_Sno

Ski_Sno: SKI/SNO/DAC family (170 - 284)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
蛋白主名 其他名称

dachshund homolog 1

dac homolog

DACH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DACH1 Q9UI36 NAGK Homo sapiens Q9UJ70
Y2H
21516116
种属内
DACH1 Q9UI36 NAGK Homo sapiens Q9UJ70
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colobomatous Microphthalmia

Anophthalmia-Microphthalmia Syndrome

Mac

Microphthalmia With Colobomatous Cyst

Microphthalmia-Anophthalmia-Coloboma Syndrome

Microphthalmia-Anophthalmia-Coloboma

Microphthalmia And Mental Deficiency
Granular Cell Carcinoma

Granular Cell Cancer

Granular Cell Adenocarcinoma
Supraglottis Neoplasm

Neoplasm Of Supraglottis

Supraglottic Tumor
Deafness, Autosomal Dominant 10

DFNA10

Autosomal Dominant Nonsyndromic Deafness 10

Autosomal Dominant Deafness 10

Deafness, Autosomal Dominant, 10

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 10

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 10

Deafness, Autosomal Dominant, Type 10
Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome

Mental Retardation, X-Linked, Snyder-Robinson Type

Spermine Synthase Deficiency

Srs

Snyder-Robinson Mental Retardation Syndrome

X-Linked Intellectual Disability Snyder-Robinson Type

Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

Snyder-Robinson X-Linked Mental Retardation Syndrome
Branchiootorenal Syndrome

Branchio-Oto-Renal Syndrome

Bor Syndrome

Branchiootorenal Dysplasia

Melnick-Fraser Syndrome

Branchiootorenal Spectrum Disorders

Branchio-Otorenal Dysplasia

Branchio Oto Renal Syndrome

Branchiootorenal/Branchiootic Syndrome

Bo Syndrome

Bor

Bos

Branchio-Otorenal Syndrome

Branchiootic Syndrome

Branchiootorenal Syndrome

Branchiootic Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03513 DACH1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DACH1 MGD MGI:1277991
Rattus norvegicus DACH1 RGD RGD:1592073
Bos taurus DACH1 VGNC VGNC:106704
Macaca mulatta DACH1 VGNC VGNC:71725
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