1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Neurotrophic Factors
  4. CDNF/MANF family
  5. CDNF
  6. CDNF 蛋白, Mouse (HEK293, His)

CDNF 蛋白, Mouse (HEK293, His)

目录号: HY-P75670
产品使用指南

CDNF(大脑多巴胺神经营养因子)作为多巴胺神经元的关键营养因子出现,可以抵消 6-羟基多巴胺 (6-OHDA) 诱导的退化。值得注意的是,它可以恢复多巴胺能功能并预防 6-OHDA 损伤后的黑质神经元变性。CDNF 蛋白, Mouse (HEK293, His) 是重组的 CDNF 蛋白,由 HEK293 表达,带有 C-His 标签。

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描述

CDNF (cerebral dopamine neurotrophic factor) emerges as a key trophic factor for dopamine neurons that counteracts 6-hydroxydopamine (6-OHDA)-induced degeneration. Notably, it can restore dopaminergic function and prevent nigral neuronal degeneration after 6-OHDA injury. CDNF Protein, Mouse (HEK293, His) is the recombinant mouse-derived CDNF protein, expressed by HEK293 , with C-His labeled tag.

研究背景

CDNF(大脑多巴胺神经营养因子)成为多巴胺神经元的关键营养因子,具有抵抗多巴胺能神经元中 6-羟基多巴胺 (6-OHDA) 诱导的退化的能力。特别值得注意的是,在 6-OHDA 诱导的损伤后给药时,它能够恢复多巴胺能功能并防止黑质神经元变性。这强调了 CDNF 在减轻多巴胺能神经元背景下神经变性的有害影响方面的潜在治疗意义,为旨在保留和恢复神经功能的干预措施提供了希望。

种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

Q8CC36 (Q25-L187)

基因 ID
蛋白结构
N-term
CDNF (Q25-L187)
Accession # Q8CC36
His
C-term
同用名
Cerebral dopamine neurotrophic factor; CDNF; ARMETL1
分子量

Approximately 20 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CDNF Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CDNF Protein, Mouse (HEK293, His)
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