Centrin-2 蛋白, Human (His)

Centrin-2 protein plays a critical role in microtubule-organized centromere structure, directing centriole duplication, spindle formation, and regulation of cytokinesis. It ensures genome stability by interacting with CALM1 and CCP110. Centrin-2 Protein, Human (His) is the recombinant human-derived Centrin-2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Centrin-2 Protein, Human (His) is 171 a.a., with molecular weight of ~20 kDa.

Centrin-2 蛋白在微管组织中心的结构和功能中发挥着重要作用，特别是在细胞分裂过程中中心粒的复制和纺锤体的正确形成中。除了在这些过程中发挥核心作用外，Centrin-2 还通过与 CALM1 和 CCP110 的协作相互作用来调节胞质分裂和维持基因组稳定性。此外，它作为 XPC 复合体的关键组成部分，错综复杂地参与全局基因组核苷酸切除修复 (GG-NER)。与 RAD23B 合作，Centrin-2 似乎可以稳定 XPC，并且在体外刺激 XPC:RAD23B 二聚体的 DNA 结合，突显其在基因组完整性和细胞分裂所必需的细胞机制中的多方面参与。

Human

E. coli

N-6*His

P41208 (A2-Y172)

1069  [NCBI]

ASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

Approximately 20 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.