Claudin-18/CLDN18.2 蛋白, Human (His)

CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by E. coli , with N-8*His labeled tag. The total length of Claudin-18/CLDN18.2 Protein, Human (His) is 49 a.a., with molecular weight of ~18.0 kDa.

CLDN18通过调节肺泡上皮细胞中紧密连接的组成、影响离子转运和溶质通透性，可能通过调节肌动蛋白细胞骨架组织和 β-在肺泡液稳态中发挥着至关重要的作用。2-肾上腺素能信号传导。CLDN18-VLP 对于肺泡化和细胞旁肺泡上皮屏障的维持至关重要，通过控制 YAP1 的亚细胞定位并限制其靶基因转录，有助于上皮祖细胞增殖和器官大小调节。此外，CLDN18-VLP 作为 RANKL 诱导的破骨细胞分化的负调节因子，可能是通过影响 TJP2/ZO-2 的亚细胞分布并参与缺钙反应的骨吸收来实现的。它们独立于 RANKL 信号通路介导雌激素的骨保护作用。此外，CLDN18-VLP 通过调节 pH 值和随后的 T 细胞激活来维持肺泡微环境稳态，间接有助于限制新型隐球菌感染。

Human

E. coli

N-8*His

P56856-2 (D28-L76)

51208  [NCBI]

DQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAML

Approximately 18.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 25 mM NaCl, 0.1% Triton X-100, 10% glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.