CLDN18 - claudin 18 Gene

中文名称：密蛋白 18

种属: Homo sapiens

同用名: SFTA5; SFTPJ

基因 ID: 51208 | 基因类型: protein coding

关于 CLDN18

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:137,998,816-138,033,649 (from NCBI)

This gene has 3 transcripts (splice variants), 234 orthologues and 22 paralogues. Biased expression in stomach (RPKM 335.4) and lung (RPKM 153.8).

功能概要

该基因编码密蛋白家族的一个成员。 Claudins 是完整的膜蛋白和紧密连接链的组成部分。紧密连接链作为物理屏障，防止溶质和水自由通过上皮或内皮细胞片之间的细胞旁空间，并且在维持细胞极性和信号转导中也起着关键作用。该基因在溃疡性结肠炎患者中上调，在浸润性导管腺癌中高度过度表达。 PKC/MAPK/AP-1 (蛋白激酶 C/丝裂原活化蛋白激酶/激活蛋白-1) 依赖性通路调节该基因在胃细胞中的表达。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2010 年 6 月]

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

CLDN18 基因产物(2)

mRNA	Protein	Name
NM_001002026.3	NP_001002026.1	claudin-18 isoform 2
NM_016369.4	NP_057453.1	claudin-18 isoform 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19706394	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLDN18 蛋白结构

PMP22_Claudin

0
100
200
261 a.a.

蛋白主名

其他名称

claudin-18

surfactant associated 5

CLDN18 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLDN18	P56856	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
种属内	CLDN18	P56856	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CLDN18 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70045	Claudin-18/CLDN18.1 Protein, Human (His)	P56856-1 (D28-L76)	≥95%
HY-P70701	Claudin-18/CLDN18.2 Protein, Human (His)	P56856-2 (D28-L76)	≥95%
HY-P78105	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293)	P56856-2 (M1-V261)	≥95%
HY-P78368	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293)	P56856-2 (M1-V261)	≥95%
HY-P700403	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His)	P56856-2 (M1-V261)	≥95%

CLDN18 抗体

目录号	产品名	应用	反应物种
HY-P81773	Claudin 18.2 Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction	Adenocarcinoma Of Gastroesophageal Junction
Adenocarcinoma Of The Gastroesophageal Junction

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Bladder Urachal Carcinoma

Urachal Cancer

Urachal Carcinoma

Urachus Cancer

Malignant Tumor Of Urachus

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Signet Ring Cell Adenocarcinoma

Signet Ring Cell Carcinoma	Carcinoma, Signet Ring Cell
Signet Ring Carcinoma	Carcinoma Signet Ring Cell

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer	HDGC
LBC	Familial Diffuse Gastric Cancer
Fdgc	Hereditary Diffuse Gastric Adenocarcinoma
Breast Cancer, Lobular	Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate
DGLBC	Gastric Cancer, Hereditary Diffuse
Gastric Cancer, Familial Diffuse Breast Cancer, Lobular	Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate
E-Cadherin-Associated Hereditary Gastric Cancer	Familial Diffuse Cancer Of Stomach
Hereditary Diffuse Cancer Of Stomach	Gastric Cancer Familial Diffuse
Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate	Cancer, Gastric, Hereditary Diffuse

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99350	Gresonitamab		99.12%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02768	CLDN18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P991027	Spevatamig		/	否
HY-P990742	Givastomig		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CLDN18	VGNC	VGNC:27408
Canis familiaris	CLDN18	VGNC	VGNC:39314
Rattus norvegicus	CLDN18	RGD	RGD:1359696
Mus musculus	CLDN18	MGD	MGI:1929209
Macaca mulatta	CLDN18	VGNC	VGNC:71248
Felis catus	CLDN18	VGNC	VGNC:60933
Macaca fascicularis	CLDN18	NCBI	NCBI:102126717
Others	CLDN18	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLDN18 - claudin 18 Gene

关于 CLDN18

功能概要

CLDN18 基因产物(2)

CLDN18 蛋白结构

CLDN18 蛋白互作信息

重组 CLDN18 蛋白

CLDN18 抗体

关联疾病

直系同源

热门区域

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CLDN18 - claudin 18 Gene

关于 CLDN18

功能概要

CLDN18 基因产物(2)

CLDN18 蛋白结构

CLDN18 蛋白互作信息

重组 CLDN18 蛋白

CLDN18 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z