CLEC1B/CLEC-2 蛋白, Human (HEK293, His)

CLEC1B/CLEC-2 protein is a C-type lectin-like receptor that acts as a platelet receptor and snake venom protein receptor for PDPN in microbial infections. Upon activation, it initiates a signaling cascade involving SRC and SYK kinases, leading to PLCG2 activation. CLEC1B/CLEC-2 Protein, Human (HEK293, His) is the recombinant human-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC1B/CLEC-2 Protein, Human (HEK293, His) is 172 a.a., with molecular weight of 35-38 kDa.

CLEC1B/CLEC-2 蛋白是一种 C 型凝集素样受体，具有作为淋巴内皮标志物 PDPN 的血小板受体的显着功能。配体激活后，它会启动信号级联，涉及 SRC 和 SYK 酪氨酸激酶的连续激活，最终导致 PLCG2 的激活。在微生物感染的情况下，CLEC1B/CLEC-2 充当血小板聚集蛇毒蛋白蛇毒蛋白的受体。红细胞素结合诱导酪氨酸磷酸化，促进脾酪氨酸激酶 (SYK) 的结合并启动下游酪氨酸磷酸化事件，同时激活 PLCG2。这种多方面的作用凸显了 CLEC1B/CLEC-2 在血小板功能和免疫反应中的参与，特别是在与 PDPN 和视红细胞素相互作用的情况下。

Measured by its binding ability in a functional ELISA.

Human

HEK293

N-His

Q9P126 (Q58-P229)

51266  [NCBI]

QRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP

35-38 kDa

Greater than 80% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.