Cochlin/COCH 蛋白, Human (HEK293, His)

Cochlin/COCH protein is involved in regulating cell shape and motility in the trabecular meshwork. It exists as a monomer and may form homodimers. Additionally, Cochlin interacts with type II collagen, SLC44A2, and ANXA2. Cochlin/COCH Protein, Human (HEK293, His) is the recombinant human-derived Cochlin/COCH protein, expressed by HEK293 , with N-His labeled tag. The total length of Cochlin/COCH Protein, Human (HEK293, His) is 526 a.a., with molecular weight of ~66 & 48 & 18 kDa, respectively.

耳蜗蛋白 (COCH) 蛋白在协调小梁网内细胞形状和运动方面发挥着关键作用。Cochlin 作为单体存在，还表现出形成同型二聚体的潜力。它与 II 型胶原蛋白的相互作用凸显了它参与细胞外基质动力学。此外，Cochlin 与 SLC44A2 进行重要的相互作用，强调其在细胞过程中的作用。此外，它与 ANXA2 的关联强调了它参与对细胞功能至关重要的复杂分子网络。

Human

HEK293

N-10*His

O43405 (E25-Q550)

1690  [NCBI]

EGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ

Approximately 66&48&18 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.