CORS26 蛋白, Mouse (Myc, His)

CORS26 Protein is a secreted protein of the C1q/ TNF-associated protein (CTRPs) family. CORS26 Protein involved in the LAMP1-STAT3, SIRT1/NF-魏B/p53, NF-魏B and TGF-尾1/Smad3 pathways play anti-inflammatory effects. CORS26 Protein also inhibited the expression of antimicrobial peptide (CAMP) in adipocytes induced by toll-like receptors (TLR). CORS26 Protein, Mouse (Myc, His) is the recombinant mouse-derived CORS26 protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of CORS26 Protein, Mouse (Myc, His) is 224 a.a., with molecular weight of ~31.1 kDa.

C1q/ TNF 相关蛋白 (CTRPs) 是一类具有特定结构的分泌蛋白家族。Complement C1q tumor necrosis factor-related protein 3 通过 LAMP1-STAT3 轴在银屑病中显示抗炎作用。C1qtnf3 通过 SIRT1/NF-κB/p53 轴改善蛋白诱导的小鼠严重急性胰腺炎。C1qtnf3 调节 NF-κB 和 TGF-β1/Smad3通路，减轻 ovalbumin (OVA) 致哮喘小鼠气道炎症和重塑。C1qtnf3 可抑制 toll 样受体 (TLR) 诱导的脂肪细胞中抗菌肽 (CAMP) 的表达。

Mouse

E. coli

N-His;C-Myc

Q9ES30 (23Q-246K)

81799  [NCBI]

QDEYMESPQAGGLPPDCSKCCHGDYGFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGVPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYETKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

Approximately 31.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.