Crlf1 蛋白, Mouse (HEK293, His, solution)

Crlf1 protein combines with CLCF1 to form an important neurotrophic cytokine involved in neuronal development. It plays a crucial role in the initiation and maintenance of lactation in neonatal mice and is associated with immune system regulation. Crlf1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Crlf1 protein, expressed by HEK293 , with His labeled tag. The total length of Crlf1 Protein, Mouse (HEK293, His, solution) is 386 a.a., with molecular weight of ~75.0 kDa.

Crlf1 蛋白与 CLCF1 结合形成对神经元发育至关重要的异二聚体神经亲和细胞因子。它在新生小鼠哺乳的启动和/或维持中起着至关重要的作用，并且与免疫系统内的潜在调节功能有关。Crlf1 蛋白表现出共价二聚体和四聚体的形成，并且它参与与心肌营养素样细胞因子 CLCF1/CLC 的异聚复合物的形成。这种 CRLF1-CLCF1 复合物充当睫状神经营养因子受体/CNTFR 的配体。值得注意的是，CRLF1-CLCF1 异二聚体与 CRLF1、CLCF1 和 CNTFR 形成的三联信号复合物结合 SORL1，其中相互作用主要由该复合物内的 CRLF1 部分介导。这些复杂的相互作用强调了 Crlf1 蛋白在神经发育过程和免疫调节中的多方面作用。

Mouse

HEK293

C-His

Q9JM58 (G40-G425)

12931  [NCBI]

GAHTAVISPQDPTLLIGSSLQATCSIHGDTPGATAEGLYWTLNGRRLPSELSRLLNTSTLALALANLNGSRQQSGDNLVCHARDGSILAGSCLYVGLPPEKPFNISCWSRNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDVLDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGVCEPRGGEPSSGPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGAARGPAG

Approximately 65-75 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 8.0 or PBS PH7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.