2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  5. CTLA-4 CTLA-4
  6. CTLA-4 蛋白, Canine (HEK293, Fc)

CTLA-4 蛋白, Canine (HEK293, Fc)

目录号: HY-P75321
产品使用指南

CTLA-4 蛋白作为关键负调节因子抑制 T 细胞反应，对 CD80 和 CD86 的亲和力比 CD28 更强。这种亲和力使 CTLA-4 能够有效抑制 T 细胞活化并调节免疫反应，维持 T 细胞介导的免疫的微妙平衡。CTLA-4 蛋白, Canine (HEK293, Fc) 是重组的 CTLA-4 蛋白，由 HEK293 表达，带有 C-hFc 标签。CTLA-4 蛋白, Canine (HEK293, Fc) 全长 161 个氨基酸，分子量约为 ~40.1 kDa。

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描述

CTLA-4 protein inhibits T-cell responses as a critical negative regulator, with a stronger affinity for CD80 and CD86 than CD28. This affinity allows CTLA-4 to effectively suppress T-cell activation and regulate immune responses, maintaining a delicate equilibrium in T-cell-mediated immunity. CTLA-4 Protein, Canine (HEK293, Fc) is the recombinant canine-derived CTLA-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CTLA-4 Protein, Canine (HEK293, Fc) is 161 a.a., with molecular weight of ~40.1 kDa.
研究背景

CTLA-4 蛋白作为关键的抑制性受体发挥作用，作为 T 细胞反应的主要负调节因子发挥着关键作用。CTLA-4 的显着特征在于其对其天然 B7 家族配体 CD80 和 CD86 的亲和力明显强于其相应刺激辅助受体 CD28 的亲和力。这种增强的亲和力使 CTLA-4 能够有效平衡和抑制 T 细胞激活，从而有助于免疫反应的复杂调节。CTLA-4 及其配体之间的动态相互作用强调了其在微调免疫系统以及维持 T 细胞介导的免疫激活和抑制之间的微妙平衡方面的重要性。
种属

Canine
表达系统

HEK293
标签

C-hFc
蛋白编号

Q9GKP2 (K36-D161)
基因 ID
蛋白结构
N-term
CTLA-4 (K36-D161)
Accession # Q9GKP2
hFc
C-term
同用名
Cytotoxic T-lymphocyte associated protein 4; CTLA4; CD152
分子量

Approximately 40.1 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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