IP-10/CXCL10 蛋白, Rhesus macaque (His)

CXCL10 protein acts as a chemotactic factor for monocytes and T-lymphocytes, playing a crucial role in their migration in response to inflammatory signals. Through binding to CXCR3, CXCL10 selectively attracts monocytes and T-lymphocytes, positioning it as a key player in immune responses, contributing to the recruitment and activation of these immune cells in various physiological and pathological contexts. IP-10/CXCL10 Protein, Rhesus macaque (His) is the recombinant Rhesus Macaque-derived CXCL10 protein, expressed by E. coli , with N-6*His labeled tag.

CXCL10 蛋白是单核细胞和 T 淋巴细胞的趋化因子，在协调它们响应炎症信号的迁移中发挥着至关重要的作用。通过与 CXCR3 的结合，CXCL10 建立了一种分子相互作用，促进其化学吸引功能。这种对单核细胞和 T 淋巴细胞的选择性趋化性使 CXCL10 成为免疫反应中的关键参与者，有助于在各种生理和病理环境中招募和激活这些免疫细胞。

Measured in a cytotoxicity assay using HUVEC Human Umbilical Vein Endothelial Cells. The ED₅₀ for this effect is 42.55 pg/mL, corresponding to a specific activity is 2.350×10⁷ units/mg.

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  Measured in a cytotoxicity assay using HUVEC Human Umbilical Vein Endothelial Cells. The ED₅₀ for this effect is 42.55 pg/mL, corresponding to a specific activity is 2.350×10⁷ units/mg.

Rhesus Macaque

E. coli

N-6*His

Q8MIZ1 (I22-P98)

574243  [NCBI]

IPLSRTVRCTCISISNQPVNPRSLEKLEIIPPSQFCPHVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

Approximately 11 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.