CXCR2 蛋白, Human (Cell-Free, His)

CXCR2, the receptor for interleukin-8 (IL-8), orchestrates neutrophil activation through a G-protein-mediated phosphatidylinositol-calcium second messenger system upon IL-8 binding. Exhibiting high-affinity binding to IL-8, CXCR2 also interacts with other ligands like CXCL3, GRO/MGSA, and NAP-2. The involvement of GNAI2 underscores the intricate signaling mechanisms regulating neutrophil function through CXCR2. CXCR2 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR2, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CXCR2 Protein, Human (Cell-Free, His) is 360 a.a.,

CXCR2 是白细胞介素 8 (IL-8) 的受体，是一种有效的中性粒细胞趋化因子，在 IL-8 结合后协调中性粒细胞的激活。这种反应是通过 G 蛋白介导的，启动磷脂酰肌醇-钙第二信使系统。CXCR2 不仅与 IL-8 表现出高亲和力结合，还与其他配体（例如 CXCL3、GRO/MGSA 和 NAP-2）表现出高亲和力结合。与 IL-8 和 GNAI2 的相互作用进一步凸显了 CXCR2 调节中性粒细胞功能所涉及的复杂信号机制。

Human

E. coli Cell-free

N-10*His

P25025 (M1-L360)

3579

MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

Observed band size: Monomer: 42 kDa Dimer: 84 kDa. It is speculated that the protein forms a dimeric structure.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.