CXCR2 蛋白, Human (His-SUMO)

CXCR2, the receptor for interleukin-8 (IL-8), orchestrates neutrophil activation through a G-protein-mediated phosphatidylinositol-calcium second messenger system upon IL-8 binding. Exhibiting high-affinity binding to IL-8, CXCR2 also interacts with other ligands like CXCL3, GRO/MGSA, and NAP-2. The involvement of GNAI2 underscores the intricate signaling mechanisms regulating neutrophil function through CXCR2. CXCR2 Protein, Human (His-SUMO) is the recombinant human-derived CXCR2 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of CXCR2 Protein, Human (His-SUMO) is 40 a.a., with molecular weight of 20.6 kDa.

CXCR2 是白细胞介素 8 (IL-8) 的受体，是一种有效的中性粒细胞趋化因子，在 IL-8 结合后协调中性粒细胞的激活。这种反应是通过 G 蛋白介导的，启动磷脂酰肌醇-钙第二信使系统。CXCR2 不仅与 IL-8 表现出高亲和力结合，还与其他配体（例如 CXCL3、GRO/MGSA 和 NAP-2）表现出高亲和力结合。与 IL-8 和 GNAI2 的相互作用进一步凸显了 CXCR2 调节中性粒细胞功能所涉及的复杂信号机制。

Human

E. coli

N-SUMO;N-6*His

P25025 (M1-E40)

3579  [NCBI]

MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCE

20.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of Tris-based buffer, 50% glycerol, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.