Cyclophilin A 蛋白, Mouse (His)

Cyclophilin A (PPIA) protein, with integrin binding and peptidyl-prolyl cis-trans isomerase activity, influences platelet aggregation and neuron differentiation. It is found in the extracellular space and myelin sheath, showing ubiquitous expression in various tissues, including the liver and central nervous system. PPIA is associated with cholangiocarcinoma and HIV disease, suggesting its role in fundamental cellular processes. Cyclophilin A Protein, Mouse (His) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with C-His labeled tag.

亲环蛋白 A (PPIA) 蛋白具有整联蛋白结合活性和肽基-脯氨酰顺反异构酶活性。这种多功能蛋白质参与血小板聚集，并在神经元分化相关过程的上游发挥作用。亲环蛋白 A 位于细胞外空间和髓鞘中，有助于其功能多样性。编码这种蛋白质的基因在各种组织中普遍表达，包括肝脏、中枢神经系统和早期发育阶段的许多其他结构。人类直向同源物 PPIA 的影响包括其与胆管癌和人类免疫缺陷病毒感染性疾病的关联。这种广泛的表达模式表明亲环蛋白 A 参与多个组织的基本细胞过程。

Measured by its ability to inhibit calcineurin phosphatase activity in the presence of Cyclosporin A. The IC₅₀ for inhibition of calcineurin activity is 432.059 nM that incubate at 37 ºC for 60 minutes.

Mouse

E. coli

C-His

P17742/NP_032933.1 (M1-L164)

268373  [NCBI]

MVNPTVFFDITADDEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGDFTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITISDCGQL

Approximately 18.94 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4, 10% glycerol or 20 mM PB, 150 mM NaCl, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.