2. 重组蛋白
  3. Enzymes & Regulators
  4. Isomerases (EC 5)
  5. Cyclophilin B/PPIB 蛋白, Human (HEK293, His)

Cyclophilin B/PPIB 蛋白, Human (HEK293, His)

目录号: HY-P70011A
产品使用指南

亲环蛋白 B/PPIB 蛋白是一种肽基脯氨酰顺反异构酶 (PPIase)，可催化脯氨酸酰亚胺肽键的顺反异构化，并可能有助于蛋白质折叠。这种重要的酶作用凸显了其在确保多肽链适当构象变化方面的重要性，这对于功能成熟至关重要。Cyclophilin B/PPIB 蛋白, Human (HEK293, His) 是重组的 亲环蛋白 B/PPIB 蛋白，由 HEK293 表达，带有 C-6*His 标签。Cyclophilin B/PPIB 蛋白, Human (HEK293, His) 全长 179 个氨基酸，分子量约为 ~19 kDa。

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规格 价格 是否有货
5 μg ￥450 询问价格 & 货期
10 μg ￥770 询问价格 & 货期
50 μg ￥2150 询问价格 & 货期
100 μg ￥3650 询问价格 & 货期

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描述

Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, His) is 179 a.a., with molecular weight of ~19 kDa.
研究背景

Cyclophilin B/PPIB 蛋白作为肽基脯氨酰顺反异构酶 (PPIase)，积极参与寡肽中脯氨酸酰亚胺肽键顺反异构化的催化，从而可能有助于促进蛋白质折叠。这种酶功能强调了蛋白质在促进多肽链适当构象变化的动态过程中的作用，这对于其功能成熟至关重要。作为复杂的蛋白质折叠领域的关键参与者，亲环蛋白 B/PPIB 通过促进新生或错误折叠多肽的正确折叠，在维持细胞蛋白质稳态中发挥着至关重要的作用。这些 PPIase 活性的精确协调强调了该蛋白质在细胞生理学中的重要性，需要进一步探索以揭示亲环蛋白 B/PPIB 促进蛋白质折叠动力学的特定分子机制和细胞途径。
种属

Human
表达系统

HEK293
标签

C-6*His
蛋白编号

P23284 (D34-A212)
基因 ID
蛋白结构
N-term
PPIB (D34-A212)
Accession # P23284
6*His
C-term
同用名
Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4
氨基酸序列

DEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFA

分子量

Approximately 19 kDa
纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cyclophilin B/PPIB Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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