DCK/Deoxycytidine kinase 蛋白, Human (P. pastoris, His)

DCK/Deoxycytidine kinase Protein efficiently phosphorylates deoxyribonucleosides, including deoxycytidine, deoxyguanosine, and deoxyadenosine, showcasing broad substrate specificity without chirality selectivity. As an indispensable enzyme, DCK plays a crucial role in phosphorylating nucleoside analogs, vital in antiviral and chemotherapeutic treatments. Its catalytic ability contributes to therapeutic efficacy in nucleoside analog-based therapies, emphasizing its significance in cellular processes. DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) is the recombinant human-derived DCK/Deoxycytidine kinase protein, expressed by P. pastoris, with C-6*His labeled tag. The total length of DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) is 260 a.a., with molecular weight of 31.6 kDa.

DCK 被称为脱氧胞苷激酶，通过有效磷酸化脱氧核糖核苷（包括脱氧胞苷、脱氧鸟苷和脱氧腺苷）来展示其酶促能力。该激酶具有广泛的底物特异性，不会表现出基于底物手性的选择性。其重要性延伸至成为常用作抗病毒和化疗剂的各种核苷类似物磷酸化不可或缺的酶。DCK 催化核苷磷酸化的能力在细胞过程中起着至关重要的作用，并有助于基于核苷类似物的治疗的疗效。

Human

P. pastoris

C-6*His

P27707 (M1-L260)

1633  [NCBI]

MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL

31.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.