DHFR 蛋白, Human (His)

DHFR protein, a pivotal enzyme in folate metabolism, is crucial for multiple pathways. It catalyzes reactions essential for de novo mitochondrial thymidylate biosynthesis, de novo glycine and purine synthesis, and DNA precursor synthesis. Beyond its catalytic role, DHFR binds its own mRNA and DHFR2 mRNA, hinting at a regulatory role in self-expression control and potential influence on related cellular processes. DHFR Protein, Human (His) is the recombinant human-derived DHFR protein, expressed by E. coli , with N-6*His labeled tag.

二氢叶酸还原酶 (DHFR) 是叶酸代谢中的关键酶，在多种重要途径中发挥着至关重要的作用。它对从头线粒体胸苷酸生物合成途径有显着贡献，催化对从头甘氨酸和嘌呤合成以及 DNA 前体合成至关重要的反应。除了其催化功能外，DHFR 还表现出结合其自身 mRNA 和 DHFR2 mRNA 的能力，从而表明在控制其自身表达方面具有调节作用，并可能影响相关的细胞过程。

Human

E. coli

N-6*His

P00374-1 (M1-D187)

1719  [NCBI]

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.