DKK-1 蛋白, Rat (HEK293, His, solution)

DKK-1 Protein, with co-receptor and lipoprotein receptor binding activities, crucially regulates ossification and neuron death positively. Primarily located in the extracellular space, DKK-1 is implicated in anodontia, showing biased expression in kidney (RPKM 4.7), brain (RPKM 0.6), and two other tissues. Its role in the WNT signaling pathway and impact on visual epilepsy highlight its significance in developmental and neurological contexts. DKK-1 Protein, Rat (HEK293, His, solution) is the recombinant rat-derived DKK-1 protein, expressed by HEK293 , with C-His labeled tag.

预计 DKK-1 蛋白在辅助受体结合、低密度脂蛋白颗粒受体结合和受体拮抗剂活性中发挥关键作用。它参与骨化的负调节和神经元死亡的正调节，其主要定位在细胞外空间。该蛋白与无牙有关，其偏向表达模式很明显，在肾脏 (RPKM 4.7)、大脑 (RPKM 0.6) 和其他两种组织中观察到显着水平。DKK-1 参与 WNT 信号通路及其对视觉癫痫的影响，使其成为发育和神经系统中的重要因素。

Measured by its ability to inhibit Wnt3a induced alkaline phosphatase production by C3H10 T1/2 cells and the ED₅₀ for this effect is typically 0.05-0.3 μg/mL.

Rat

HEK293

C-His

A6I0Z0/NP_001099820.1 (T32-H270)

293897  [NCBI]

MTVVRAVAAVRFLVVLSTMALCSLPPLGVSATLNSVLINSNAIKNLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGTDEYCSSPSRGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHLPRGEIEEGIIENLGNDHGAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCATGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLACRIQKDHHQTSNSSRLHTCQRH

Approximately 27.4 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.