DSC2/Desmocollin-2 蛋白, Rat (HEK293, His)

DSC2 (or Desmocollin-2) is an important component of desmosome connections between cells and plays a key role in the complex interaction network between plaque proteins and intermediate filaments. At these junctions, DSC2 contributes to cell-cell adhesion, promoting tissue cohesion and stability. DSC2/Desmocollin-2 Protein, Rat (HEK293, His) is the recombinant rat-derived DSC2/Desmocollin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DSC2/Desmocollin-2 Protein, Rat (HEK293, His) is 666 a.a., with molecular weight of ~80-95 KDa, respectively.

Desmocollin-2 (DSC2) 是细胞间桥粒连接的重要组成部分，在细胞间粘附中发挥着关键作用。作为桥粒的一部分，DSC2 有助于介导细胞间相互作用的复杂网络。这些连接对于维持组织完整性至关重要，并通过斑块蛋白和中间丝的相互作用提供结构支持。DSC2 参与该分子复合物强调了其在确保组织（尤其是承受机械应力的组织）的内聚力和稳定性方面的重要性。该蛋白质促进细胞间粘附的功能凸显了其在维持组织结构和整体细胞完整性中的重要性。（参考：提供的资料）

Measured by the ability of the immobilized protein to support the adhesion of the Caki-2 human clear cell carcinoma epithelial cells. The adhesion rate for this effect is 75.84% in the presence of 10 μg/mL Rat DSC2.

Rat

HEK293

C-His

Q3T1K6 (C29-P694)

291760  [NCBI]

CDACKEVVLQVPSELPAGKFVGRVNLMECLKSANVIHLSDPDFQVFEDGSVYTTNSVVLSSGQRSFTIWLFNTDSQEERELSVHLEGPVEVLNQRLHTEKVLRRAKRRWAPIPCSMMENSLGPFPLFLQQIQSDKAQNYTIYYSISGPGVDKEPVGLFRIDRDTGNLYCTDRVDREQYDSFELTALAMTPDGYMVENLLTLLIKVEDENDNYPIFTQKVYSFTVLENSPFGSHVGEVCATDKDEPDTMHTRLKYSILEQSPSPPMLFTMHPRTGVITTTSTQLDRELIDKYQLIIKVQDMDGQYFGLQTTATCVITIGDVNDNLPTFTRTTYVTSVEENTVNVELLRLSVQDKDLVNSPNWRANYTILKGNENGNFKIKTDPQTNEGILCVIMPLDYEERQRVTLEIGVVNEAPYTRQAGSKSSMSTATVTVNVKNQDEGPECIPQTQTVRIRENVPIGTRNDGYKAYDPETKNSIGIRYRKLSDPKGWITVNEDSGSITIFRTLDREAETIRNGIYNITVLALDADGRSCTGTLGILLEDVNDNGPFIPKQTVVICRATMSSAEIVAVDPDEPANGPPFDFSLESSDSEVRRRWKLTRINDTAASLSYQNDPAFDSYVIPVRVTDRFGLSSVTSLNVVVCDCITESDCTYRTGERTGYADVRLGP

Approximately 80-95 kDa due to the glycosylation

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.