DSG3 蛋白, Human (Baculovirus, His)

DSG3 is a component of intercellular desmosome junctions and plays a key role in promoting intercellular adhesion by participating in important interactions with plaque proteins and intermediate filaments. Carefully orchestrated interactions between DSG3 and these structural elements are critical for maintaining the integrity and strength of cell-to-cell connections. DSG3 Protein, Human (Baculovirus, His) is the recombinant human-derived DSG3 protein, expressed by Sf9 insect cells , with C-6*His labeled tag. The total length of DSG3 Protein, Human (Baculovirus, His) is 566 a.a., with molecular weight of 67 kDa.

Desmoglein-3 (DSG3) 是细胞间桥粒连接的重要组成部分，在介导细胞间粘附方面发挥着至关重要的作用。DSG3 在这些连接处发挥作用，参与斑块蛋白和中间丝之间的相互作用，有助于组织的结构完整性和稳定性。值得注意的是，DSG3 与 Plakophilin-2 (PKP2) 相互作用，强调了其在协调桥粒复合物的组装和维护中的作用。这种相互作用进一步凸显了细胞间粘附所涉及的复杂分子网络，并强化了 DSG3 通过参与桥粒信号通路确保组织正常功能和结构凝聚力的重要性。（参考：提供的资料）

Measured by its binding ability in a functional ELISA. Immobilized Human DSG3 at 2 μg/mL can bind Anti-DSG3 recombinant antibody , the EC₅₀ is <5.720 ng/mL.

Human

Sf9 insect cells

C-6*His

P32926 (E50-R615)

1830  [NCBI]

EWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGR

67 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.