DSG3 - desmoglein 3 Gene

中文名称：桥粒芯糖蛋白 3

种属: Homo sapiens

同用名: PVA; ABOLM; CDHF6

基因 ID: 1830 | 基因类型: protein coding

关于 DSG3

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:31,447,741-31,478,702 (from NCBI)

This gene has 1 transcript (splice variant), 390 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward esophagus (RPKM 200.1).

功能概要

该基因编码桥粒芯糖蛋白家族和钙粘蛋白细胞粘附分子蛋白质超家族的成员。桥粒核心糖蛋白是桥粒的钙结合跨膜糖蛋白成分，桥粒是上皮细胞、心肌细胞和其他细胞类型之间的细胞-细胞连接。编码的前原蛋白经过蛋白水解处理以生成成熟的糖蛋白。该基因与 18 号染色体上的其他桥粒芯糖蛋白基因家族成员存在于基因簇中。编码的蛋白质已被鉴定为自身免疫性水疱病寻常型天疱疮的自身抗原。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and Other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with Other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]

DSG3 基因产物(1)

mRNA	Protein	Name
NM_001944.3	NP_001935.2	desmoglein-3 preproprotein

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11790773	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	30949721	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DSG3 蛋白结构

Cadherin

Cadherin_C

0
200
400
600
800
999 a.a.

蛋白主名

其他名称

desmoglein-3

130 kDa pemphigus vulgaris antigen

重组 DSG3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72174	DSG3 Protein, Human (His-SUMO)	P32926 (E50-R615)	≥95%
HY-P700469	DSG3 Protein, Human (Baculovirus, His)	P32926 (E50-R615)	≥95%

关联疾病

疾病名称

别名

Blistering, Acantholytic, Of Oral And Laryngeal Mucosa

ABOLM

Pemphigus

Pemphigus Vulgaris, Familial

Pemphigus Vulgaris	Familial Pemphigus Vulgaris
Pemphigus

Pemphigus Foliaceus

Pemphigus Foliaceous	Pf
Superficial Pemphigus

Herpetiform Pemphigus

Bullous Skin Disease

Skin Diseases Bullous

Skin Diseases, Bullous

Bullous Pemphigoid

Benign Pemphigus	Senile Dermatitis Herpetiformis
Old Age Pemphigus	Parapemphigus
Pemphigoid	Pemphigoid Bullous
Pemphigoid, Bullous

Impetigo

Pemphigoid

Aphthous Stomatitis

Oral Ulcer	Canker Sore
Aphtha	Aphthous Ulceration
Oral Aphthae	Oral Aphthous Ulcer
Canker Sores	Stomatitis, Aphthous
Minor Oral Aphthous Ulceration

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Subcorneal Pustular Dermatosis

Subcorneal Pustular Dermatitis	Sneddon-Wilkinson Disease Or Syndrome
Pustulosis Subcornealis	Sneddon-Wilkinson Disease
Skin Diseases, Vesiculobullous	Vesiculobullous Skin Disease

Lichen Planus

Lichen Ruber Planus	Lichen, Ruber Planus
Ruber Planus	Lp - [Lichen Planus]
Lichen Planus Of Wilson	Wilson Lichen Ruber

Pemphigus Erythematosus

Seborrheic Pemphigus

Senear-Usher Syndrome

Iga Pemphigus

Paraneoplastic Pemphigus

Bullous Impetigo

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Autoimmune Disease Of Skin And Connective Tissue

Pemphigoid Gestationis

Herpes Gestationis	Gestational Pemphigoid
Gestational Herpes

Mucositis

Inflammatory Disease Of Mucous Membrane

Gastrointestinal Mucositis

Pemphigus Gestationis

Pseudomembranous Conjunctivitis

Hidradenitis

Hydradenitis

Lichen Disease

Benign Chronic Pemphigus

Hailey-Hailey Disease	Pemphigus, Benign Familial
Familial Benign Pemphigus	Benign Familial Pemphigus
Familial Benign Chronic Pemphigus	BCPM
HHD	Benign Chronic Familial Pemphigus Of Hailey-Hailey
Pemphigus, Chronic, Benign

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Cicatricial Pemphigoid

Mucous Membrane Pemphigoid	Ocular Pemphigoid
Benign Mucous Membrane Pemphigoid	Benign Mucous Membrane Pemphigoid With Ocular Involvement
Benign Mucosal Pemphigoid	Pemphigoid, Benign Mucous Membrane
Cicatricial Pemphigoid With Ocular Involvement	Ocular Pemphigus
Cicatricial Pemphigoid Disease	Mucosal Pemphigoid
Mucosynechial Pemphigoid	Pemphigoid Cicatricial
Cicatricial Pemphigoid Involving The Eye	Ocular Cicatricial Pemphigoid

Darier-White Disease

Keratosis Follicularis	Darier Disease
Darier'S Disease	DAR
DD	Darier White Disease
Darier Disease Acral Hemorrhagic Type	Darier Disease Segmental
Darier Disease, Acral Hemorrhagic Type	Darier Disease, Segmental

Adenoid Squamous Cell Carcinoma

Acantholytic Squamous Cell Carcinoma	Adenocarcinoma With Squamous Metaplasia
Adenoacanthoma	Pseudoglandular Squamous Carcinoma

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Integumentary System Disease

Familial Woolly Hair Syndrome

Wooly Hair	Familial Wooly Hair Syndrome
Hereditary Woolly Hair Syndrome	Hereditary Wooly Hair Syndrome
Woolly Hair	Syndrome With Woolly Hair
Wooly Hair Syndrome

Autoimmune Disease Of Musculoskeletal System

Palmoplantar Keratoderma, Nonepidermolytic

Nonepidermolytic Palmoplantar Keratoderma	NEPPK
Tylosis	Unna-Thost Syndrome
Keratoderma, Palmoplantar, Diffuse	Ppkne
Keratoderma, Nonepidermolytic Palmoplantar	Diffuse Nonepidermolytic Palmomplantar Keratoderma
Thost-Unna Syndrome	Non-Epidermolytic Palmoplantar Keratoderma
Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type	Diffuse Palmoplantar Keratoderma, Bothnian Type
Krt1-Related Diffuse Nonepidermolytic Keratoderma	Krt1-Related Diffuse Neppk
Keratoderma, Palmoplantar, Non-Epidermolytic	Nonepidermolytic Unna-Thost Disease
Non-Epidermolytic Unna-Thost Disease	Keratoderma, Palmoplantar, Nonepidermolytic
Hyperkeratosis

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04023	DSG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DSG3	MGD	MGI:99499
Bos taurus	DSG3	VGNC	VGNC:28222
Canis familiaris	DSG3	VGNC	VGNC:40107
Macaca mulatta	DSG3	VGNC	VGNC:72003
Rattus norvegicus	DSG3	RGD	RGD:1592103
Others	DSG3	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DSG3 - desmoglein 3 Gene

关于 DSG3

功能概要

DSG3 基因产物(1)

DSG3 蛋白结构

重组 DSG3 蛋白

关联疾病

直系同源

热门区域

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DSG3 - desmoglein 3 Gene

关于 DSG3

功能概要

DSG3 基因产物(1)

DSG3 蛋白结构

重组 DSG3 蛋白

关联疾病

相关产品

直系同源

热门区域

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