DTD1 蛋白, Human (HEK293, His)

The DTD1 protein, as a potential ATPase, may participate in DNA replication by helping to load CDC45 onto the prereplication complex. In addition, it can also act as an aminoacyl-tRNA editing enzyme, specifically deacylating erroneous D-aminoacyl-tRNA and erroneous glycyl-tRNA (Ala). DTD1 Protein, Human (HEK293, His) is the recombinant human-derived DTD1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DTD1 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of ~30.0 kDa.

DTD1 蛋白可能是参与 DNA 复制的 ATP 酶，可能在将 CDC45 装载到复制前复合物上方面发挥作用。此外，它还充当氨酰基-tRNA 编辑酶，专门对错误的 D-氨酰基-tRNA 和错误的甘氨酰-tRNA(Ala) 进行脱酰基处理。值得注意的是，该酶采用基于 tRNA 的催化作用，在活性位点排斥 L-氨基酸而不是检测 D-氨基酸。该活性有助于将 D-氨酰基-tRNA 回收为 D-氨基酸和游离 tRNA 分子，减轻与体内 D-氨酰基-tRNA 实体形成相关的毒性，并有助于维持蛋白质 L-同手性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

Q8TEA8 (M1-P209)

92675  [NCBI]

MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLKGNKPDFHLAMPTEQAEGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQLSKLEKQQQRKEKTRAKGPSESSKERNTPRKEDRSASSGAEGDVSSEREP

Approximately 30.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.