E-selectin/CD62E 蛋白, Cynomolgus (HEK293, His)

The E-selectin/CD62E Protein, belonging to the selectin/LECAM family, plays a crucial role in mediating cell adhesion processes, particularly interactions between leukocytes and endothelial cells. As a member of this family, E-selectin likely shares conserved features, emphasizing its significance in cellular adhesion. Its study contributes to understanding inflammatory responses, immune cell trafficking, and potential therapeutic interventions. Further exploration of E-selectin/CD62E's role promises insights into its contributions to immune surveillance, inflammation, and broader cellular processes in both normal physiology and pathology. E-selectin/CD62E Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived E-selectin/CD62E protein, expressed by HEK293, with C-His labeled tag. The total length of E-selectin/CD62E Protein, Cynomolgus (HEK293, His) is 535 a.a., with molecular weight of 95-115 kDa.

E-选择素/CD62E 蛋白是选择素/LECAM 家族的重要成员，表明其在细胞粘附过程中发挥着重要作用。作为该家族的一部分，E-选择素可能与相关蛋白质具有保守的结构和功能特征，表明其参与介导白细胞和内皮细胞之间的相互作用。选择素/LECAM家族的分类强调了其在更广泛的细胞粘附分子背景下的特定名称，提供了对其对细胞粘附的独特贡献的见解。E-选择素/CD62E的研究有助于我们了解其在炎症反应和免疫细胞运输中的作用，提供在治疗干预中的潜在应用，并更深入地理解其对参与免疫监视和炎症的细胞过程的更广泛影响。对 E-选择素/CD62E 作用的进一步探索有望增强我们对其对正常生理和病理状况的贡献的了解。

Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The ED₅₀ for this effect is 29.560 ng/mL, corresponding to a specific activity is 3.392×10⁴ units/mg.

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  Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The ED₅₀ for this effect is 29.560 ng/mL, corresponding to a specific activity is 3.392×104 units/mg.

Cynomolgus

HEK293

C-His

G8F370 (W22-P556)

/

WSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKRDKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLECEQIVNCTALESPEHGSLVCSHPLGNFSYSSSCSVSCDRGYLPSSVETTQCMSSGEWSVPIPACKVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAIRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGAAQVECTTQGQWTQQVPVCEAFQCTALSNPERGYMNCLPSASGSFRNGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPQRGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVLEKINMSCSGEPVFGTVCNFACPEGWRLNGSAAMTCGATGHWSGMLPTCEAPTESNTP

95-115 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.