EDA2R/XEDAR 蛋白, Human (HEK293, His)

The EDA2R/XEDAR protein acts as a receptor for the EDA isoform A2 (unlike A1) and is critical for activating the NF-kappa-B and JNK pathways. Its activation involves binding to TRAF3 and TRAF6. EDA2R/XEDAR Protein, Human (HEK293, His) is the recombinant human-derived EDA2R/XEDAR protein, expressed by HEK293 , with N-His labeled tag. The total length of EDA2R/XEDAR Protein, Human (HEK293, His) is 138 a.a., with molecular weight of ~23-25 kDa.

EDA2R/XEDAR 蛋白是专门针对 EDA 同工型 A2 的受体，将其与同工型 A1 区分开来。该受体在介导 NF-kappa-B 和 JNK 通路的激活中发挥着至关重要的作用。EDA2R/XEDAR 与 TRAF3 和 TRAF6 的结合似乎促进了激活过程。此外，EDA2R/XEDAR 与 TRAF1、TRAF3 和 TRAF6 形成关联，表明其参与复杂的信号网络。这些相互作用凸显了 EDA2R/XEDAR 在细胞信号通路中的多方面作用，强调其对免疫反应和炎症过程的潜在影响。

Immobilized Recombinant Human EDA-A2 at 1 μg/mL (100 μL/well) can bind Recombinant Human EDA2R. The ED₅₀ for this effect is 216.4 ng/mL.

• 
  Immobilized Recombinant Human EDA-A2 at 1 μg/ml (100 μL/well) can bind Recombinant Human EDA2R. The ED₅₀ for this effect is 216.4 ng/mL.

Human

HEK293

N-6*His

Q9HAV5 (M1-T138)

60401  [NCBI]

MDCQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQSCITCAVINRVQKVNCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVEADTPTVPPQEA

Approximately 23-25 kDa due to the glycosylation.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.