EDAR 蛋白, Human (HEK293, His)

EDAR Protein, a receptor for EDA isoform A1, activates NF-kappa-B and JNK signaling pathways upon binding, eliciting diverse cellular responses. It may also contribute to caspase-independent cell death. EDAR forms a complex with EDARADD and associates with signaling molecules like TRAF1, TRAF2, TRAF3, and NIK, highlighting its participation in intricate signaling cascades. EDAR Protein, Human (HEK293, His) is the recombinant human-derived EDAR protein, expressed by HEK293 , with C-His labeled tag. The total length of EDAR Protein, Human (HEK293, His) is 163 a.a., with molecular weight of ~25-35 kDa.

EDAR 是专门针对 EDA 同工型 A1 的受体，使其与 EDA 同工型 A2 区别开来。结合后，EDAR 促进 NF-kappa-B 和 JNK 信号通路的激活，可能导致各种细胞反应。此外，EDAR 可能在促进不依赖 caspase 的细胞死亡中发挥作用。该受体与 EDARADD 形成复合物，并与 TRAF1、TRAF2、TRAF3 和 NIK 等关键信号分子相关，表明其参与复杂的信号级联反应。

When Recombinant Human EDAR Protein is immobilized at 2 µg/mL (100 µL/well) can bind Anti- EDAR Antibody. The ED₅₀ for this effect is 66.07 ng/mL.

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  When Recombinant Human EDAR Protein is immobilized at 2 µg/mL (100 µL/well) can bind Anti- EDAR Antibody. The ED₅₀ for this effect is 66.07 ng/mL.

Human

HEK293

C-His

Q9UNE0-1 (E27-I189)

10913  [NCBI]

EYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALI

The protein migrates as an approximately 25-35 kDa band under reducing SDS-PAGE due to glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.