Endoglycan/PODXL2 蛋白, Human (HEK293, His)

The endocan/PODXL2 protein serves as a ligand for angioselectin, enabling leukocytes to rapidly roll on the vascular surface through high-affinity divalent cation-dependent interactions with E-, P-, and L-selectin. Through disulfide bonds, the protein forms homodimers and interacts with specific selectins, including SELL, SELE, and SELP. Endoglycan/PODXL2 Protein, Human (HEK293, His) is the recombinant human-derived Endoglycan/PODXL2 protein, expressed by HEK293 , with C-His labeled tag.

内聚糖/PODXL2 蛋白作为血管选择素的配体，通过与 E-、P- 和 L-选择素进行高亲和力二价阳离子依赖性相互作用，促进白细胞在血管表面快速滚动。它通过二硫键形成同二聚体，并与特定的选择素蛋白（包括 SELL、SELE 和 SELP）相互作用。这些相互作用强调了它在介导关键粘附事件中的作用，这些粘附事件有助于白细胞招募和血管稳态的复杂过程。

Human

HEK293

C-His

Q9NZ53-1 (G33-T500)

50512  [NCBI]

70-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.