EphB2 蛋白, Human (HEK293, His)

EphB2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with the transmembrane ephrin B ligand. It guides commissural axons in the developing cerebral cortex, efferent growth cones of the inner ear, and retinal ganglion cell axons. EphB2 Protein, Human (HEK293, His) is the recombinant human-derived EphB2 protein, expressed by HEK293 , with C-His labeled tag.

EphB2 蛋白是一种受体酪氨酸激酶，与邻近细胞上的跨膜肝配蛋白-B 配体相互作用，产生双向信号传导。EphB2 下游的通路称为正向信号传导，而肝配蛋白配体下游的通路称为反向信号传导。EphB2在发育过程中的轴突引导中发挥着至关重要的作用，特别是在连接大脑皮层颞叶的连合轴突的引导，以及内耳传出生长锥和视网膜神经节细胞轴突的引导中。它还调节树突棘的发育和成熟，促进兴奋性突触的形成，抵消 EFNB1 激活后 ARHGEF15 介导的负调节。此外，EphB2 参与各种发育过程，包括血管生成、上颚发育和内耳内淋巴生成。它与 EFNB2 的复合物控制尿道管状化和泄殖腔分隔过程中的细胞运动和粘附。此外，EphB2 可能具有肿瘤抑制活性，并可能影响血小板活化和凝血。

Human

HEK293

C-His

P29323-1 (V19-L543)

2048  [NCBI]

VEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPL

70-75 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.