Ephrin-B1/EFNB1 蛋白, Human (HEK293, His-Fc)

Ephrin-B1/EFNB1 Protein, a transmembrane ligand, interacts with Eph receptors, facilitating bidirectional signaling. It binds EPHB1/ELK and EPHB2/3, inducing axon collapse and growth cone orientation. EFNB1 also interacts with GRIP1/2, TLE1, and enhances ZHX2's transcriptional repression activity. These interactions highlight EFNB1's role in diverse developmental processes. Ephrin-B1/EFNB1 Protein, Human (HEK293, His-Fc) is the recombinant human-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-8*His, C-hFc labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Human (HEK293, His-Fc) is 210 a.a., with molecular weight of ~64 & 36 kDa, respectively.

Ephrin-B1/EFNB1 蛋白是一种细胞表面跨膜配体，与 Eph 受体相互作用，Eph 受体是受体酪氨酸激酶家族，对神经元、血管和上皮发育至关重要。这种结合导致相邻细胞之间依赖于接触的双向信号传导。Ephrin-B1/EFNB1 对受体酪氨酸激酶 EPHB1/ELK 显示出高亲和力，并且还可以结合 EPHB2 和 EPHB3。体外研究表明，它可以诱导连合轴突和生长锥的塌陷，表明它在定向纵向突出轴突方面发挥着作用。Ephrin-B1/EFNB1 通过其 PDZ 结合基序与 GRIP1 和 GRIP2 以及 TLE1 相互作用。此外，Ephrin-B1/EFNB1 的胞内结构域肽与 ZHX2 相互作用，增强 ZHX2 的转录抑制活性。

Human

HEK293

C-8*His;C-hFc

P98172 (L28-K237)

1947  [NCBI]

LAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNRPEQEIRFTIKFQEFSPNYMGLEFKKHHDYYITSTSNGSLEGLENREGGVCRTRTMKIIMKVGQDPNAVTPEQLTTSRPSKEADNTVKMATQAPGSRGSLGDSDGKHETVNQEEKSGPGASGGSSGDPDGFFNSK

Approximately 64&36 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.