FABP5 蛋白, Human (His)

FABP5 acts as an intracellular carrier of long-chain fatty acids and related lipids and regulates ligand metabolism. It selectively delivers specific fatty acids from the cytoplasm to the nucleus, activating nuclear receptors including peroxisome proliferator-activated receptor delta, promoting proliferation and survival. FABP5 Protein, Human (His) is the recombinant human-derived FABP5 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FABP5 Protein, Human (His) is 134 a.a., with molecular weight of ~17 kDa.

FABP5 作为长链脂肪酸和相关活性脂质（包括内源性大麻素）的细胞内载体，从而调节它们结合的配体的代谢和作用。除了在细胞质运输中的作用外，FABP5 还选择性地将特定的脂肪酸从细胞质输送到细胞核，在那里它们激活核受体。值得注意的是，它将视黄酸递送至核受体过氧化物酶体增殖物激活受体δ，促进增殖和存活。FABP5 还可以作为中枢突触内源性大麻素的突触载体，从而控制逆行内源性大麻素信号传导。此外，它在炎症过程中通过 NF-kappa-B 激活和前列腺素 E2 (PGE2) 生物合成调节 PTGES 诱导，从而调节炎症。此外，FABP5 可能参与角质形成细胞分化。

Human

E. coli

N-6*His

Q01469 (A2-E135)

2171  [NCBI]

ATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE

Approximately 17 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.