2. Gene
  3. FABP5 - fatty acid binding protein 5 Gene

FABP5 - fatty acid binding protein 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脂肪酸结合蛋白 5

种属: Homo sapiens

同用名: EFABP; KFABP; E-FABP; PAFABP; PA-FABP

基因 ID: 2171 | 基因类型: protein coding

关于 FABP5

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,280,536-81,284,775 (from NCBI)

This gene has 4 transcripts (splice variants), 447 orthologues and 15 paralogues. Biased expression in esophagus (RPKM 725.7), fat (RPKM 171.7) and 11 other tissues.

功能概要

该基因编码在表皮细胞中发现的脂肪酸结合蛋白，并首次被鉴定为在牛皮癣组织中被上调。脂肪酸结合蛋白是一个小型、高度保守的细胞质蛋白家族，可结合长链脂肪酸和其他疏水配体。 FABP 可能在脂肪酸摄取、运输和代谢中发挥作用。该基因的多态性与 2 型糖尿病有关。人类基因组包含许多与该基因座相似的假基因。[RefSeq 提供，2011 年 2 月]

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

FABP5 基因产物(1)

mRNA Protein Name
NM_001444.3 NP_001435.1 fatty acid-binding protein 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acid binding IDA
IDA: 通过直接分析推断
8092987 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
24531463 GOA
enables long-chain fatty acid transmembrane transporter activity IMP
IMP: 通过突变表型推断
21395585 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12839573 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lipid transport across blood-brain barrier IMP
IMP: 通过突变表型推断
21395585 GOA
involved in long-chain fatty acid transport IMP
IMP: 通过突变表型推断
21395585 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8092987 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24692551 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FABP5 蛋白结构

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (9 - 133)

  • 0
  • 100
  • 135 a.a.
蛋白主名 其他名称

fatty acid-binding protein 5

epidermal-type fatty acid-binding protein

重组 FABP5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72660 FABP5 Protein, Human (His) Q01469 (A2-E135) ≥95%
HY-P75214 FABP5 Protein, Human Q01469 (M1-E135) ≥95%

关联疾病

疾病名称 别名
Psoriasis
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101903 BMS-309403 Inhibitor 99.93% 否
HY-101903A BMS-309403 sodium Inhibitor 99.94% 否
HY-145990 FABPs ligand 6 Inhibitor 98.57% 否
HY-159115 ART26.12 Inhibitor 99.57% 否
HY-161702 RO6806051 Inhibitor 99.84% 否
HY-N8144 Niga-ichigoside F1 ≥99.0% 否
HY-RS04661 FABP5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-160456 FABP4/5-IN-4 Inhibitor / 否
HY-160457 FABP4/5-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FABP5 RGD RGD:70997
Felis catus FABP5 VGNC VGNC:81655
Mus musculus FABP5 MGD MGI:101790
Others FABP5 NCBI
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