1. 重组蛋白
  2. CD Antigens Fc Receptors Biotinylated Proteins
  3. Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins Fc-gamma Receptor
  4. Fc gamma RII/CD32
  5. FcγRIIB/CD32b
  6. Fc gamma RIIB/CD32b 蛋白, Cynomolgus (Biotinylated, HEK293, His-Avi)

Fc gamma RIIB/CD32b 蛋白, Cynomolgus (Biotinylated, HEK293, His-Avi)

目录号: HY-P76799
产品使用指南

Fc γ RIIB/CD32b 蛋白作为复合物或聚集免疫球蛋白 γ Fc 区的受体,表现出低亲和力。Fc γ RIIB/CD32b 磷酸化的 ITIM 募集肌醇磷酸酶 SHIP1 和SHIP2,抑制 Ras 活化,下调 MAPK 活性,降低 PLCγ 功能,导致 PKC 活化降低。抑制 MAP 激酶通路和抗凋亡激酶 Akt 抑制细胞增殖和存活。Fc gamma RIIB/CD32b 蛋白, Cynomolgus (Biotinylated, HEK293, His-Avi) 是重组的 Fc gamma RIIB/CD32b 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Fc γ RIIB/CD32b proteins exhibit low affinity as complexes or receptors that aggregate the immunoglobulin γFc region. ITIM phosphorylated by Fc γ RIIB/CD32b recruits inositol phosphatases SHIP1 and SHIP2, inhibits Ras activation, down-regulates MAPK activity, reduces PLC-γ function, and results in PKC activation. Inhibition of MAP kinase pathway and anti-apoptotic kinase Akt inhibit cell proliferation and survival. Fc gamma RIIB/CD32b Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

研究背景

Fc γ RIIB/CD32b 蛋白作为复合物或聚集免疫球蛋白 γ Fc 区的受体,表现出低亲和力。它在多种效应和调节功能中起关键作用,包括免疫复合物的吞噬和 B 细胞抗体产生的调节。与该受体结合后,通过 B 细胞 (BCR)、T 细胞 (TCR) 或另一种 Fc 受体上的抗原受体触发细胞激活的先前状态下调。IIB1 亚型不能介导内吞作用或吞噬作用,而 IIB2 亚型不诱导吞噬作用。Fc γ RIIB/CD32b 与INPP5D/SHIP1、FGR 和 LYN 相互作用。Fc γ RIIB/CD32b 磷酸化的 ITIM 募集肌醇磷酸酶 SHIP1 和SHIP2,抑制 Ras 活化,下调 MAPK 活性,降低 PLCγ 功能,导致 PKC 活化降低。抑制 MAP 激酶通路和抗凋亡激酶 Akt 抑制细胞增殖和存活。

种属

Cynomolgus

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

Q8SPW3 (A45-G220)

基因 ID
蛋白结构
N-term
CD32b (A45-G220)
Accession # Q8SPW3
Avi-His
C-term
同用名
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2
分子量

Approximately 34 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Fc gamma RIIB/CD32b Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)
目录号:
HY-P76799
需求量: