Fc gamma RIIB/CD32b 蛋白, Rat (HEK293, His)

Fc gamma RIIB/CD32b Protein plays a crucial role, specifically binding to the Fc region of immunoglobulins gamma as a low-affinity receptor. Binding to IgG, it initiates cellular responses against pathogens, highlighting its immune system modulation. Interactions with FGR and LYN underscore its role in signaling pathways, emphasizing its significance in mediating cellular responses and contributing to immune defense against diverse antigens. Fc gamma RIIB/CD32b Protein, Rat (HEK293, His) is the recombinant rat-derived Fc gamma RIIB/CD32b protein, expressed by HEK293, with C-His labeled tag. The total length of Fc gamma RIIB/CD32b Protein, Rat (HEK293, His) is 181 a.a., with molecular weight of 30-50 KDa.

Fc gamma RIIB/CD32b 蛋白发挥着至关重要的作用，因为它特异性结合免疫球蛋白 gamma 的 Fc 区域，充当低亲和力受体。通过与 IgG 结合，Fc gamma RIIB/CD32b 启动针对病原体和可溶性抗原的细胞反应，凸显其参与免疫系统调节。该蛋白与 FGR 和 LYN 的相互作用进一步强调了其在复杂信号通路中的作用，强调了其在介导细胞反应和促进针对不同抗原的免疫防御机制中的重要性。

Measured by its binding ability in a functional ELISA. Immobilized Rat CD32b, at 2 μg/mL (100 μL/well) can bind Biotinylated Human IgG1 protein. The ED₅₀ for this effect is 0.3838 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Rat CD32b, at 2 μg/mL (100 μL/well) can bind Biotinylated Human IgG1 protein. The ED₅₀ for this effect is 0.3838 μg/mL.

Rat

HEK293

C-His

Q63203 (H32-P212)

289211  [NCBI]

HAGLPKAVVKLEPPWIQVLKEDTVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKATVNDSGEYRCRMEETGISEPIHLGVISDWLLLQTSQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQEPKSSSSLP

30-50 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.