Fc gamma RIIIB/CD16b 蛋白, Human (NA2, HEK293, His)

Fc gamma RIIIB/CD16b Protein, a low-affinity receptor for IgG, binds complexed or monomeric IgG. Unlike Fc gamma RIIIA, it cannot mediate antibody-dependent cytotoxicity or phagocytosis. Instead, Fc gamma RIIIB may act as a trap for immune complexes, circulating without activating neutrophils. Existing as a monomer, it interacts with INPP5D/SHIP1, implying its role in intracellular signaling pathways linked to immune responses. Fc gamma RIIIB/CD16b Protein, Human (NA2, HEK293, His) is the recombinant human-derived Fc gamma RIIIB/CD16b protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fc gamma RIIIB/CD16b Protein, Human (NA2, HEK293, His) is 192 a.a., with molecular weight of 35-65 kDa.

Fc gamma RIIIB/CD16b 蛋白充当免疫球蛋白 gamma Fc 区的受体，表现出低亲和力并与复合或聚集的 IgG 以及单体 IgG 结合。与 Fc γ RIIIA 相比，Fc γ RIIIB 缺乏介导抗体依赖性细胞毒性和吞噬作用的能力。相反，它可能充当外周循环免疫复合物的陷阱，而不激活中性粒细胞。该蛋白以单体形式存在，并与 INPP5D/SHIP1 相互作用，表明其参与与免疫反应相关的细胞内信号传导途径。

Human

HEK293

C-6*His

O75015 (G17-Q208)

2215  [NCBI]

GMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQ

35-65 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.