1. 重组蛋白
  2. Enzymes & Regulators
  3. Protein Tyrosine Kinases
  4. FES Proto-Oncogene, Tyrosine Kinase
  5. FES 蛋白, Human (His)

FES 蛋白, Human (His)

目录号: HY-P702719
产品使用指南

FES 是一种酪氨酸蛋白激酶,可调节细胞过程,包括肌动蛋白动力学和细胞扩散。它影响肥大细胞中 FCER1 介导的信号传导、KIT 受体途径和 NGF 诱导的神经突生长。FES 有助于 HGF 触发的细胞散射和迁移,磷酸化 BCR 和 HCLS1/HS1 等蛋白质,从而影响细胞信号传导途径。FES 蛋白, Human (His) 是重组的 FES 蛋白,由 E. coli 表达,带有 His 标签。FES 蛋白, Human (His) 全长 375 个氨基酸

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描述

FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES Protein, Human (His) is the recombinant human-derived FES, expressed by E. coli , with His labeled tag. The total length of FES Protein, Human (His) is 375 a.a.,

研究背景

FES 是一种酪氨酸蛋白激酶,在细胞表面受体下游发挥作用,有助于调节各种细胞过程,包括肌动蛋白细胞骨架动力学、微管组装、细胞附着和细胞扩散。它在肥大细胞中 FCER1 介导的信号传导中发挥着至关重要的作用,影响肥大细胞脱粒,并作用于 KIT 受体的下游。此外,FES 还参与细胞分化,响应 NGF 信号传导促进神经突生长。它有助于 HGF 诱导的 EZR 激活引发的细胞分散和迁移。FES 磷酸化 BCR 等关键蛋白,导致 BCR 激酶活性以及 HCLS1/HS1、PECAM1、STAT3 和 TRIM28 下调,强调其在细胞信号通路中的多种调节功能。

种属

Human

表达系统

E. coli

标签

His

蛋白编号

P07332-1 (I448-R822)

基因 ID

2242

同用名
Tyrosine-protein kinase Fes/Fps; Proto-oncogene c-Fes; FES; FPS
纯度

Greater than 80 % as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FES Protein, Human (His)
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HY-P702719
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