Fetuin A/AHSG 蛋白, Human (HEK293, His)

Fetuin A (or AHSG protein) plays multiple roles in cellular processes, promotes endocytosis and displays opsonic properties. It regulates the mineral phase of bone, affects bone homeostasis, and has significant affinity for calcium and barium ions. Fetuin A/AHSG Protein, Human (HEK293, His) is the recombinant human-derived Fetuin A/AHSG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fetuin A/AHSG Protein, Human (HEK293, His) is 349 a.a., with molecular weight of ~60.0 kDa.

胎球蛋白 A，也称为 AHSG 蛋白，在细胞过程中扮演着多方面的角色，积极促进内吞作用并显示调理特性。它的影响延伸到骨矿物相的调节，反映了它在骨稳态中的作用。胎球蛋白 A 对钙离子和钡离子具有显着的亲和力，有助于细胞环境中的离子相互作用。连接肽裂解后，前体产生 α-2-HS 糖蛋白，两条链 A 和 B 通过单个二硫键错综复杂地连接。这种分子结构强调了胎球蛋白 A 的结构复杂性及其对各种生理过程的潜在影响，需要进一步研究以揭示其在细胞和骨生物学中不同功能背后的详细机制。

Measured by its ability to inhibit calcium phosphate precipitation. The IC₅₀ value is 46.163 μg/mL, as measured under the described conditions.

Human

HEK293

C-6*His

AAH48198.1/NP_001613.2 (A19-V367)

197  [NCBI]

APHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCTVFQTQPVTSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV

Approximately 60.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.