FGF-13 蛋白, Human

FGF-13 Protein, a microtubule-binding protein, directly binds and stabilizes tubulin, influencing microtubule polymerization. It negatively regulates axonal and leading process branching, crucial for neuron polarization and migration in the cerebral cortex and hippocampus. Additionally, FGF-13 regulates voltage-gated sodium channel transport and function, potentially impacting MAPK signaling. Interactions with SCN8A, SCN1A, SCN5A, SCN2A, and SCN11A suggest a role in modulating sodium channel activity and MAPK8IP2 scaffolding. FGF-13 Protein, Human is the recombinant human-derived FGF-13 protein, expressed by E. coli , with tag free. The total length of FGF-13 Protein, Human is 245 a.a., with molecular weight of ~27.6 kDa.

FGF-13 是一种微管结合蛋白，与微管蛋白直接相互作用，参与微管的聚合和稳定。这种微管动力学的参与表明，通过负向调节轴突和主导过程的分支，在轴突的细化中发挥作用。此外，FGF-13 在大脑皮层和海马内神经元的极化和迁移中起着至关重要的作用。它进一步调节电压门控钠通道的转运和功能，影响特定钠通道亚型的活性。除了与微管相关的功能外，FGF-13 还参与吊灯神经元促进的轴突起始段靶向抑制性 GABA 能突触的发育。通过其多样化的相互作用，包括与各种钠通道和 MAPK 信号传导成分的相互作用，FGF-13 在控制神经元过程和突触功能的复杂调节网络中发挥着多方面的作用。

Human

E. coli

Tag Free

Q92913-1 (M1-T245)

2258  [NCBI]

MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST

Approximately 27.6 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, pH 8.5, 500 mM NaCl.

<1 EU/μg; determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.