FGF-6 蛋白, Human

FGF-6 Protein, Human is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells.

成纤维细胞生长因子 6 (FGF-6) 是 FGF 家族的肝素结合成员，是细胞增殖、分化和功能的调节因子。FGF-6 与 FGF 受体 1c、2c 和 4^[1] 结合并发出信号。FGF-6 是成纤维细胞、血管内皮细胞和前列腺癌细胞的有效有丝分裂原^[2]。

The ED₅₀ is <2.5 ng/mL as measured by 3T3 cells, corresponding to a specific activity of >4.0 × 10⁵ units/mg.

Human

E. coli

Tag Free

P10767 (G41-I208)

2251  [NCBI]

MGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI

Approximately 18.8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Ornitz DM, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7.  [Content Brief]

  [2]. Ropiquet F, et al. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. Cancer Res. 2000 Aug 1;60(15):4245-50.  [Content Brief]