FGF6 - fibroblast growth factor 6 Gene

中文名称：成纤维细胞生长因子 6

种属: Homo sapiens

同用名: HST2; HBGF-6

基因 ID: 2251 | 基因类型: protein coding

关于 FGF6

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,434,142-4,445,815 (from NCBI)

This gene has 3 transcripts (splice variants), 269 orthologues and 21 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。当转染到哺乳动物细胞中时，该基因显示出致癌转化活性。该基因的小鼠同系物主要在肌源性谱系中表现出受限的表达谱，这表明在肌肉再生或分化中起作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

FGF6 基因产物(1)

mRNA	Protein	Name
NM_020996.3	NP_066276.2	fibroblast growth factor 6 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	8663044	GOA
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: 通过遗传相互作用推断	8663044	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FGF6 蛋白结构

FGF

0
100
208 a.a.

蛋白主名

其他名称

fibroblast growth factor 6

FGF-6

FGF6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FGF6	P10767	NCALD	Homo sapiens	P61601	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FGF6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7174	FGF-6 Protein, Human	P10767 (G41-I208)	≥95%
HY-P700068AF	Animal-Free FGF-6 Protein, Human (His)	P10767 (G41-I208)	≥95%

关联疾病

疾病名称

别名

Apert Syndrome

Acrocephalosyndactyly Type I	Acs1
Acrocephalosyndactylia	Acrocephalosyndactyly
Acs I	Apert-Crouzon Disease
Acrocephalosyndactyly Type 1	Acrocephalosyndactyly, Type I
Acs 1	Acrocephalo-Syndactyly Type 1
Syndactylic Oxycephaly	Apert'S Syndrome
Type I Acrocephalosyndactyly	APRS

Nasal Cavity Adenocarcinoma

Adenocarcinoma Of Nasal Cavity

Adenocarcinoma Of The Nasal Cavity

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04904	FGF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FGF6	MGD	MGI:95520
Felis catus	FGF6	VGNC	VGNC:62254
Canis familiaris	FGF6	VGNC	VGNC:40852
Bos taurus	FGF6	VGNC	VGNC:28981
Rattus norvegicus	FGF6	RGD	RGD:620130
Macaca mulatta	FGF6	VGNC	VGNC:108343

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FGF6 - fibroblast growth factor 6 Gene

关于 FGF6

功能概要

FGF6 基因产物(1)

FGF6 蛋白结构

FGF6 蛋白互作信息

重组 FGF6 蛋白

关联疾病

直系同源

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FGF6 - fibroblast growth factor 6 Gene

关于 FGF6

功能概要

FGF6 基因产物(1)

FGF6 蛋白结构

FGF6 蛋白互作信息

重组 FGF6 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z