FGF-14 蛋白, Canine

Fibroblast growth factor 14 is a bioactive protein found in the brain and pituitary gland that promotes fibroblast growth and is involved in embryonic development, angiogenesis, tissue repair and other processes. FGF-14 plays a neuroprotective role in in vitro Alzheimer's disease (AD) models by inhibiting MAPK signaling. FGF-14 Protein, Canine is the recombinant canine-derived FGF14 protein, expressed by E. coli , with tag free.

成纤维细胞生长因子 14 是一种存在于大脑和脑垂体中的生物活性蛋白，它促进成纤维细胞生长，参与胚胎发育、血管生成、组织修复等过程。作为 FGF 同源因子家族的成员，FGF14 在发育和成熟的神经系统中表达，通过调节神经元的可塑性和兴奋性来维持正常的神经系统功能。FGF14 基因的突变是神经退行性脊髓小脑性共济失调 (SAC27) 的原因，FGF14 缺乏会损害海马齿状回细胞的成熟，从而可能导致精神分裂症。FGF14 通过抑制 MAPK 信号传导在体外阿尔茨海默病 (AD) 模型中发挥神经保护作用。

Measured by its binding ability in a functional ELISA. When Recombinant Canine FGF14 is present at 2 μg/mL, can bind Recombinant Human FGFR4. The ED₅₀ for this effect is 299.1 ng/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Canine FGF14 is present at 2 μg/mL, can bind Recombinant Human FGFR4.The ED₅₀ for this effect is 299.1 ng/mL.

Canine

E. coli

Tag Free

XP_003363267.1 (K64-T252)

100050897  [NCBI]

KNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKAGVTPSKSTSASAIMNGGKPVNKSKTT

Approximately 21 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.