FGF-21 蛋白, Hamster (HEK293, His)

FGF21 is a liver factor that signals through the FGF21 receptor in the paraventricular nucleus of the hypothalamus to regulate monosaccharide intake and preference for sweets. FGF21 promotes the progression of non-small cell lung cancer by activating the SIRT1/PI3K/AKT signaling pathway. FGF21 plays an important role in embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 Protein, Hamster (HEK293, His) is the recombinant FGF-21 protein, expressed by HEK293 , with C-His labeled tag.

成纤维细胞生长因子 21 是成纤维细胞生长因子 (FGF) 家族的成员。FGF 家族成员具有广泛的有丝分裂和细胞存活活性，参与多种生物学过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。FGF21 是一种肝因子，即肝脏分泌的一种激素，通过下丘脑室旁核的 FGF21 受体发出信号，调节单糖的摄入和对甜食的偏好，并与伏隔核内多巴胺神经传递减少有关。FGF21 通过激活 SIRT1/PI3K/AKT 信号通路促进非小细胞肺癌进展。

Hamster FGF21, His Tag immobilized on CM5 Chip can bind Human Beta Klotho, His Tag with an affinity constant of 264.50 nM as determined in SPR assay (Biacore T200).

Others

HEK293

C-His

XP_005084765.1 (R29-S209)

101842115  [NCBI]

Approximately 21.16 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.