2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  4. FGF Family Stem Cell CD Proteins Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR-2 FGFR
  6. FGFR-2
  7. FGFR-2 beta (IIIb) 蛋白, Mouse (HEK293, His)

FGFR-2 beta (IIIb) 蛋白, Mouse (HEK293, His)

目录号: HY-P77661
产品使用指南

FGFR-2 beta 是一种酪氨酸蛋白激酶，作为成纤维细胞生长因子的细胞表面受体，对细胞调节、增殖、分化、迁移和凋亡至关重要。它在胚胎发育、滋养层功能、肢芽、肺、成骨和皮肤发育中发挥重要作用。FGFR-2 beta (IIIb) 蛋白, Mouse (HEK293, His) 是重组的 FGFR-2 beta (IIIb) 蛋白，由 HEK293 表达，带有 C-His 标签。FGFR-2 beta (IIIb) 蛋白, Mouse (HEK293, His) 全长 225 个氨基酸，分子量为 50-70 kDa。

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描述

FGFR-2 beta is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factor and is critical for cell regulation, proliferation, differentiation, migration, and apoptosis. It plays important roles in embryonic development, trophoblast function, limb buds, lungs, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-2 beta, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His) is 225 a.a., with molecular weight of 50-70 kDa.
研究背景

FGFR-2 beta 是一种酪氨酸蛋白激酶，作为成纤维细胞生长因子的细胞表面受体，在细胞增殖、分化、迁移和凋亡以及胚胎发育的复杂调节中发挥着关键作用。它对于正常胚胎模式、滋养层功能、肢芽发育、肺形态发生、成骨和皮肤发育是不可或缺的。此外，FGFR-2β 对于成骨细胞分化、增殖和凋亡的调节至关重要，对正常骨骼发育有显着贡献。在促进角质形成细胞和未成熟成骨细胞增殖的同时，诱导分化成骨细胞凋亡。通过 PLCG1、FRS2 和 PAK4 的磷酸化，FGFR-2 beta 在配体结合后启动多种信号级联反应。PLCG1 的激活导致二酰基甘油和肌醇 1,4,5-三磷酸的产生。此外，FRS2 的磷酸化会触发 GRB2、GAB1、PIK3R1 和 SOS1 的募集，介导 RAS、MAPK1/ERK2、MAPK3/ERK1、MAP 激酶信号通路和 AKT1 信号通路的激活。FGFR2 信号传导通过泛素化、内化和降解过程受到严格调控。破坏 FGFR-2 正常成熟、内化或降解的突变会导致异常信号传导，包括组成型激酶激活。FGFR-2 的过度表达促进 STAT1 的激活。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

P21803-2 (P39-E263)
基因 ID
蛋白结构
N-term
FGFR-2 beta (IIIb) (P39-E263)
Accession # P21803-2
His
C-term
同用名
Fibroblast growth factor receptor 2; FGFR-2; KGFR; K-sam; Keratinocyte growth factor receptor; CD332; BEK; KSAM
分子量

50-70 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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