2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  4. FGF Family Stem Cell CD Proteins Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR-3 FGFR
  6. FGFR-3
  7. FGFR-3 蛋白, Mouse (HEK293, His-Fc)

FGFR-3 蛋白, Mouse (HEK293, His-Fc)

目录号: HY-P73056
产品使用指南

EGFR 蛋白是一种受体酪氨酸激酶，与 EGF 家族的配体结合。EGFR 蛋白 参与 NF-kappa-B 、RAS-RAF-MEK-ERK、PI3 kinase-AKT、PLCgamma-PKC and STATs 信号通路的调节。EGFR 蛋白 具有钙调素结合活性、表皮生长因子结合活性以及表皮生长因子激活受体的活性。FGFR-3 蛋白, Mouse (HEK293, His-Fc) 是重组的 FGFR-3 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。

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SPR 检测服务   重组蛋白定制服务

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规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

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描述

The FGFR-3 Protein is a member of the fibroblast growth factor receptor family. FGFR-3 Protein regulates chondrocyte differentiation and chondrocyte proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 mutations are also associated with sperm cell tumors. FGFR-3 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
研究背景

FGFR-3 是成纤维细胞生长因子受体家族的一员，在软骨、大脑、肠道和肾脏等组织中表达。FGFR-3蛋白通过调节骨化在骨生长中发挥作用。FGFR-3 是软骨内和膜性骨化的重要调节因子，作为长骨生长的负调节因子。FGFR-3 突变也与精子细胞肿瘤有关。FGFR-3 通过激活 MAPK/STAT 信号通路调节软骨细胞分化，以及调节软骨细胞增殖。
种属

Mouse
表达系统

HEK293
标签

C-hFc;C-His
蛋白编号

Q7TSI8 (E21-Y367)
基因 ID
蛋白结构
N-term
FGFR-3 (E21-Y367)
Accession # Q7TSI8
hFc-His
C-term
同用名
Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4
氨基酸序列

MVVPACVLVFCVAVVAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELMETDEAGSVY

分子量

100-110 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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目录号：
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