2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators Biotinylated Proteins
  4. FGF Family Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR-4 FGFR
  6. FGFR-4
  7. FGFR-4 蛋白, Human (Biotinylated, HEK293, His)

FGFR-4 蛋白, Human (Biotinylated, HEK293, His)

目录号: HY-P77549
产品使用指南

FGFR-4 蛋白是一种酪氨酸蛋白激酶和成纤维细胞生长因子的细胞表面受体，可调节多种细胞过程，如增殖、分化、迁移、脂质代谢和胆汁酸生物合成。值得注意的是，它有助于响应 FGF19 下调胆汁酸合酶 CYP7A1。FGFR-4 蛋白, Human (Biotinylated, HEK293, His) 是重组的 FGFR-4 蛋白，由 HEK293 表达，带有 C-His 标签。

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描述

The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag.
研究背景

FGFR-4 蛋白是一种酪氨酸蛋白激酶，充当成纤维细胞生长因子的细胞表面受体。它在调节细胞增殖、分化、迁移、脂质代谢、胆汁酸生物合成、葡萄糖摄取、维生素 D 代谢和磷酸盐稳态中发挥着至关重要的作用。其重要功能之一是响应 FGF19，促进胆汁酸合成关键酶 CYP7A1 的下调。配体结合后，FGFR-4 磷酸化 PLCG1 和 FRS2，导致各种信号级联的激活。这种激活导致二酰基甘油和肌醇 1,4,5-三磷酸的产生，它们是重要的细胞信号分子。此外，FRS2 的磷酸化会触发 GRB2、GAB1、PIK3R1 和 SOS1 的募集，从而激活 RAS、MAPK1/ERK2、MAPK3/ERK1 和 AKT1 信号通路。FGFR-4 还促进基质蛋白酶 MMP14 的 SRC 依赖性磷酸化，并促进其溶酶体降解。FGFR-4 的信号传导通过受体内化和降解受到严格调节，MMP14 在此过程中提供帮助。然而，导致组成型激酶激活或损害正常 FGFR-4 失活的突变可能导致信号传导异常。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P22455-1 (L22-D369)
基因 ID
蛋白结构
N-term
FGFR-4 (L22-D369)
Accession # P22455-1
His
C-term
同用名
Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF
分子量

Approximately 60.8 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FGFR-4 Protein, Human (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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