1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  3. FGF Family Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. FGFR-4 FGFR
  5. FGFR-4
  6. FGFR-4 蛋白, Rhesus Macaque (HEK293, Fc)

FGFR-4 蛋白, Rhesus Macaque (HEK293, Fc)

目录号: HY-P76928
产品使用指南

FGFR-4 蛋白是酪氨酸激酶和成纤维细胞生长因子的细胞表面受体。FGFR4 是一种在癌细胞中高表达的 FGF-1FGF-3 的受体,通过激活 Mek/ErkMMP-7 促进结肠癌的肿瘤进展。FGFR-4 蛋白, Rhesus Macaque (HEK293, Fc) 是重组的 FGFR-4 蛋白,由 HEK293 表达,带有 C-mFc 标签。FGFR-4 蛋白, Rhesus Macaque (HEK293, Fc) 全长 369 个氨基酸,分子量约为 ~65.6 KDa。

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描述

The FGFR-4 protein is a cell surface receptor for tyrosine kinase and fibroblast growth factor. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7. FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is 369 a.a., with molecular weight of ~65.6 KDa.

研究背景

FGFR-4 蛋白作为酪氨酸激酶和成纤维细胞生长因子的细胞表面受体,在调节多种途径中发挥关键作用,包括细胞增殖、分化、迁移、脂质代谢、胆汁酸生物合成、维生素 D 代谢、葡萄糖摄取和磷酸盐稳态。在结构上,该蛋白包括一个具有三个免疫球蛋白样结构域的细胞外区域,一个疏水膜跨段和一个细胞质酪氨酸激酶结构域。通过其与成纤维细胞生长因子相互作用的细胞外部分,FGFR-4 启动下游信号级联,最终影响有丝分裂和分化。该基因表现出广泛的表达,在肺 (RPKM 16.7)、肾 (RPKM 12.5) 和其他 15 个组织中观察到水平升高,强调了其在不同器官的不同生理环境中的潜在意义。FGFR4 是一种在癌细胞中高表达的 FGF-1FGF-3 的受体,通过激活 Mek/ErkMMP-7 促进结肠癌的肿瘤进展。

种属

Rhesus Macaque

表达系统

HEK293

标签

C-mFc

蛋白编号

XP_001087243 (M1-D369)

基因 ID
蛋白结构
N-term
FGFR-4 (M1-D369)
Accession # XP_001087243
mFc
C-term
同用名
Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF
分子量

Approximately 65.6 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FGFR-4 Protein, Rhesus Macaque (HEK293, Fc)
目录号:
HY-P76928
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