FGL1 蛋白, Cynomolgus (HEK293, His)

Fibrinogen like 1 (FGL1) is a proliferation- and metabolism-related protein secreted by the liver. FGL1 is also upregulated in tumor tissues. FGL1 is a checkpoint ligand of lymphocyte activation gene 3 (LAG3). When binding to LAG3, FGL1 can inhibit T cell activation and proliferation. FGL1 can be used for research of immune checkpoint therapy. FGL1 plays a role in proliferation, metabolism, apoptosis, epithelial-to-mesenchymal transition, and immune infiltration^[1][2][3][4]. FGL1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGL1 Protein, Cynomolgus (HEK293, His) is 290 a.a., with molecular weight of ~35 kDa.

纤维蛋白原样 1 (FGL1) 也称为 HFREP-1 或肝素 (HPS)，是肝脏分泌的一种增殖和代谢相关蛋白。FGL1 是新发现的淋巴细胞激活基因 3 (LAG3) 的检查点配体。FGL1 与 LAG3 结合，可以抑制 T 细胞的活化和增殖，因此 FGL1 可以增强抗肿瘤 T 细胞反应，可用于免疫检查点治疗的研究。除了在肝脏中高表达外，FGL1 在肿瘤组织中也上调 (如肺、前列腺、黑色素瘤、结直肠、乳腺癌和脑肿瘤) 并介导 EMT 过程。FGL1 是一种分子量大约为 68-KD 的蛋白质，由二硫键连接的同二聚体组成^[1][2][3]。
此外，FGL1 作为肝脏保护因子，在肝损伤时通过促进线粒体有丝分裂来加速肝细胞的生长，FGL1 在增殖、代谢、凋亡、上皮间质转化和免疫浸润等方面发挥作用^[3][4]。

Cynomolgus

HEK293

C-6*His

A0A2K5X990 (L23-I312)

102118020

LEDCAQEQVRLRAQVRLLETRVKQQQVKIKQLLQENEVQFLDKGEENSVIDLGSKRQYADCSEIFNDGYKLSGFYKIKPLQSPAEFAVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQKHGEYWLGNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGSFHPEVQWWATHQRMKFSTWDRDHDNYDGNCAEEDQSGWWFNRCHSANLNGLYYTGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRPNDFIPNVI

Approximately 35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.