2. 重组蛋白
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. FGL-1
  6. FGL1 蛋白, Cynomolgus (sf9, His)

FGL1 蛋白, Cynomolgus (sf9, His)

目录号: HY-P77367
产品使用指南

FGL1 是一种特异性的肝细胞丝裂原，调节增殖因子表达，促进肝再生，修复肝损伤。FGL1 通过与 LAG3 结合抑制 T 细胞活化。FGL1 通过激活 ERK/p-ERK 通路，促进细胞增殖。FGL1 通过抑制 PARP1/caspase 3 通路抑制非小细胞肺癌 (NSCLC) 细胞凋亡。FGL1 蛋白, Cynomolgus (sf9, His) 是重组的 FGL1 蛋白，由 Sf9 insect cells 表达，带有 C-His 标签。FGL1 蛋白, Cynomolgus (sf9, His) 全长 312 个氨基酸，分子量约为 ~35.40 KDa。

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描述

FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FGL1 Protein, Cynomolgus (sf9, His) is 312 a.a., with molecular weight of ~35.40 KDa.
研究背景

纤维蛋白原样蛋白 1 是纤维蛋白原家族的一员，是一种特异性的肝细胞丝裂原。FGL1 调节增殖因子表达，促进肝再生，修复肝损伤。FGL1 通过与 LAG3 结合抑制 T 细胞活化。FGL1 通过激活 ERK/p-ERK 通路，促进细胞增殖。FGL1 通过抑制 PARP1/caspase 3 通路抑制非小细胞肺癌 (NSCLC) 细胞凋亡。
种属

Cynomolgus
表达系统

Sf9 insect cells
标签

C-His
蛋白编号

XP_005562748 (M37-I348)
基因 ID
蛋白结构
N-term
FGL1 (M37-I348)
Accession # XP_005562748
His
C-term
同用名
Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1
分子量

Approximately 35.40 kDa.
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FGL1 Protein, Cynomolgus (sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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