Fibulin-3 蛋白, Human (HEK293, His)

Fibulin-3 protein can bind to the EGF receptor (EGFR), stimulate EGFR autophosphorylation and activate downstream signaling pathways. It may act as a negative regulator of chondrocyte differentiation, affecting cell adhesion and migration. Fibulin-3 Protein, Human (HEK293, His) is the recombinant human-derived Fibulin-3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Fibulin-3 Protein, Human (HEK293, His) is 476 a.a., with molecular weight of 55-60 kDa.

Fibulin-3 蛋白具有与 EGF 受体 (EGFR) 结合的能力，刺激 EGFR 自身磷酸化并随后激活下游信号通路。它被认为对细胞粘附和迁移具有影响，并且可能作为软骨细胞分化的负调节因子。在嗅觉上皮中，Fibulin-3 蛋白可能调节神经胶质细胞迁移和分化，并影响神经胶质细胞支持神经元轴突生长的能力。它与 ECM1 和 TIMP3 蛋白相互作用。

Immobilized Human EFEMP1, His Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-EFEMP1 Antibody, hFc Tag with the EC₅₀ of ≤20 ng/mL determined by ELISA.

Human

HEK293

N-His

Q12805 (Q18-F493)

2202  [NCBI]

55-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.