1. 重组蛋白
  2. CD Antigens Fluorescent-labeled Recombinant Proteins
  3. Platelet CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins
  4. LAT1/CD98
  5. FITC-Labeled CD98 蛋白, Human (HEK293, His)

FITC-Labeled CD98 蛋白, Human (HEK293, His)

目录号: HY-P701272
产品使用指南

CD98 蛋白充当伴侣,促进功能性转运蛋白异二聚体的生物发生和运输至质膜。它与各种 SLC7 家族转运蛋白形成异二聚体,并影响氨基酸逆向转运蛋白的底物特异性。FITC-Labeled CD98 蛋白, Human (HEK293, His) 是重组的 FITC 标记的 CD98 蛋白,由 HEK293 表达,带有 His 标签。FITC-Labeled CD98 蛋白, Human (HEK293, His) 全长 425 个氨基酸,分子量为 55-66 kDa。

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描述

The CD98 protein acts as a chaperone, promoting the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. It forms heterodimers with various SLC7 family transporters and affects the substrate specificity of amino acid antiporters. FITC-Labeled CD98 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD98 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled CD98 Protein, Human (HEK293, His) is 425 a.a., with molecular weight of 55-66 kDa.

研究背景

CD98 蛋白作为伴侣,有助于功能性转运蛋白异二聚体的生物发生和运输至质膜。它与各种 SLC7 家族转运蛋白形成异二聚体,包括 SLC7A5、SLC7A6、SLC7A7、SLC7A8、SLC7A10 和 SLC7A11,充当氨基酸反向转运蛋白,其底物特异性由 SLC7A 亚基决定。例如,异二聚体 SLC3A2/SLC7A11 通过介导细胞外阴离子 L-胱氨酸和细胞内 L-谷氨酸的交换而发挥逆向转运蛋白的作用。此外,SLC3A2/SLC7A5 与 LAPTM4B 结合时,会被募集至溶酶体,促进亮氨酸摄取和 mTORC1 激活。CD98 对于各种 SLC7 转运蛋白的质膜定位、稳定性和转运活性至关重要。此外,它在调节整合素相关信号传导方面发挥着关键作用,有助于细胞扩散、迁移和肿瘤进展。在丙型肝炎病毒 (HCV) 感染的情况下,SLC3A2 和 SLC7A5/LAT1 复合物促进病毒进入宿主细胞并增加 L-亮氨酸摄取,从而增强 mTORC1 信号激活并促进 HCV 介导的发病机制。

种属

Human

表达系统

HEK293

标签

His

蛋白编号

P08195-1 (R206-A630)

基因 ID

6520

同用名
SLC3A2; CD98; 4F2; 4F2HC; 4T2HC; CD98HC; MDU1; NACAE
分子量

55-66 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FITC-Labeled CD98 Protein, Human (HEK293, His)
目录号:
HY-P701272
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